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Rxfp2 Gene Detail
Summary
  • Symbol
    Rxfp2
  • Name
    relaxin/insulin-like family peptide receptor 2
  • Synonyms
    Gpr106, Great, LGR8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153463
    NCBI Gene: 140498
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:149942140-150005649 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 89.23 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2145 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153463
 protein coding gene Chr5:149941487-150006015 (+)
129S1/SvImJ ENSMUSG00200010062
 protein coding gene Chr5:143785491-143848194 (+)
A/J ENSMUSG00195004788
 protein coding gene Chr5:143394125-143456957 (+)
AKR/J ENSMUSG00220014872
 protein coding gene Chr5:142401871-142464496 (+)
BALB/cJ ENSMUSG00180002946
 protein coding gene Chr5:143796458-143859285 (+)
C3H/HeJ ENSMUSG00175010906
 protein coding gene Chr5:145637215-145700041 (+)
C57BL/6NJ ENSMUSG00215000040
 protein coding gene Chr5:143333518-143396173 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028057
 protein coding gene Chr5:143589801-143653947 (+)
CAST/EiJ ENSTCUG00005009208
 protein coding gene Chr5:142914462-142977449 (+)
CBA/J ENSMUSG00210000597
 protein coding gene Chr5:144523582-144586238 (+)
DBA/2J ENSMUSG00185040238
 protein coding gene Chr5:147493702-147556351 (+)
FVB/NJ ENSMUSG00205000120
 protein coding gene Chr5:143175301-143238144 (+)
JF1/MsJ ENSUMUG00000048060
 protein coding gene Chr5:149993739-150056550 (+)
LP/J ENSMUSG00230000960
 protein coding gene Chr5:151502117-151564803 (+)
NOD/ShiLtJ ENSMUSG00190005654
 protein coding gene Chr5:143149547-143212227 (+)
NZO/HlLtJ ENSMUSG00225008336
 protein coding gene Chr5:159239488-159302141 (+)
PWK/PhJ ENSLUMG00010000257
 protein coding gene Chr5:142258464-142321195 (+)
SPRET/EiJ ENSMSPG00010006122
 protein coding gene Chr5:145040233-145103614 (+)
WSB/EiJ ENSIUOG00005013346
 protein coding gene Chr5:145919378-145982032 (+)



Homology
more
  • Human Ortholog
    RXFP2, relaxin family peptide receptor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RXFP2, relaxin family peptide receptor 2
  • Synonyms
    GPR106, GREAT, INSL3R, LGR8, LGR8.1, RXFPR2
  • Links
    NCBI Gene ID: 122042
    UniProt: Q8WXD0

  • Chr Location
    13q13.1; chr13:31739526-31803389 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RXFP2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 4 alleles in 4 genetic backgrounds
    19 phenotypes from multigenic genotypes
    1 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male homozygotes for a targeted null mutation exhibit bilateral intraabdominal cryptorchidism and sterility associated with a failure in the differentiation of the gubernaculae, ligaments that control testicular movement during development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    81
  • cDNA Data
    10
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053368 Ensembl Gene Model | MGI Sequence Detail 63510 C57BL/6J ±  kb
    transcript ENSMUST00000065745 Ensembl | MGI Sequence Detail 2539 Not Applicable  
    polypeptide ENSMUSP00000067897 Ensembl | MGI Sequence Detail 737 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 11
      Primer pair 6

      Microarray probesets 2
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 7
      Phenotypes 28
    • Earliest
      J:134392 Zhao S, et al., Tyrosinase-related protein 2 promoter targets transgene expression to ocular and neural crest-derived tissues. Dev Biol. 1999 Dec 1;216(1):154-63
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory