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Mmp28 Gene Detail
Summary
  • Symbol
    Mmp28
  • Name
    matrix metallopeptidase 28 (epilysin)
  • Synonyms
    epilysin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153062
    NCBI Gene: 118453
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:83331594-83353890 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 50.39 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    585 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153062
 protein coding gene Chr11:83331594-83353897 (-)
129S1/SvImJ ENSMUSG00200051202
 protein coding gene Chr11:80451592-80473887 (-)
A/J ENSMUSG00195039618
 protein coding gene Chr11:80306041-80328336 (-)
AKR/J ENSMUSG00220047107
 protein coding gene Chr11:80528021-80550313 (-)
BALB/cJ ENSMUSG00180034801
 protein coding gene Chr11:80520696-80542999 (-)
C3H/HeJ ENSMUSG00175036468
 protein coding gene Chr11:80453066-80475361 (-)
C57BL/6NJ ENSMUSG00215041718
 protein coding gene Chr11:80104312-80126616 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016875
 protein coding gene Chr11:78677687-78700026 (-)
CAST/EiJ ENSTCUG00005040324
 protein coding gene Chr11:79980522-80002942 (-)
CBA/J ENSMUSG00210034234
 protein coding gene Chr11:80270690-80292985 (-)
DBA/2J ENSMUSG00185036026
 protein coding gene Chr11:80605972-80628262 (-)
FVB/NJ ENSMUSG00205041757
 protein coding gene Chr11:80408253-80430558 (-)
JF1/MsJ ENSUMUG00000021974
 protein coding gene Chr11:80925450-80947867 (-)
LP/J ENSMUSG00230028148
 protein coding gene Chr11:81620838-81643133 (-)
NOD/ShiLtJ ENSMUSG00190037923
 protein coding gene Chr11:80620594-80642897 (-)
NZO/HlLtJ ENSMUSG00225037921
 protein coding gene Chr11:83754215-83776519 (-)
PWK/PhJ ENSLUMG00010023341
 protein coding gene Chr11:80440274-80462738 (-)
SPRET/EiJ ENSMSPG00010038066
 protein coding gene Chr11:80833998-80857013 (-)
WSB/EiJ ENSIUOG00005034768
 protein coding gene Chr11:80428661-80451037 (-)



Homology
more
  • Human Ortholog
    MMP28, matrix metallopeptidase 28
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MMP28, matrix metallopeptidase 28
  • Synonyms
    EPILYSIN, MM28, MMP-25, MMP-28
  • Links
    NCBI Gene ID: 79148
    UniProt: Q9H239

  • Chr Location
    17q12; chr17:35756249-35795707 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null homozygote mice have enhanced chemotaxis of macrophages into the lung upon infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    624
  • Tissues
    23
  • cDNA Data
    7
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 118453 NCBI Gene Model | MGI Sequence Detail 22297 C57BL/6J ±  kb
transcript NM_001320300 RefSeq | MGI Sequence Detail 3528 C57BL/6  
polypeptide NP_001307229 RefSeq | MGI Sequence Detail 520 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 7
    Primer pair 1
    Antibodies 1

    Microarray probesets 1
References
more
  • Summaries
    All 44
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 23
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory