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Rims2 Gene Detail
Summary
  • Symbol
    Rims2
  • Name
    regulating synaptic membrane exocytosis 2
  • Synonyms
    2810036I15Rik, mKIAA0751, RIM2, Syt3-rs
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152972
    NCBI Gene: 116838
  • Alliance
    genome feature page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:39061681-39547768 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 15.45 cM, cytoband C
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12519 from dbSNP Build 142
  • Strain Annotations
    24
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152972
 protein coding gene Chr15:39061656-39547768 (+)
129S1/SvImJ ENSMUSGG00200054568
 protein coding gene Chr15:36245086-36304243 (+)
A/J ENSMUSG00195033949
 protein coding gene Chr15:36461048-36488083 (+)
A/J ENSMUSGG00195055364
 protein coding gene Chr15:36192826-36253916 (+)
AKR/J ENSMUSG00220027115
 protein coding gene Chr15:36374599-36401638 (+)
AKR/J ENSMUSGG00220054778
 protein coding gene Chr15:36108354-36167486 (+)
BALB/cJ ENSMUSG00180030877
 protein coding gene Chr15:36432523-36466306 (+)
BALB/cJ ENSMUSGG00180055445
 protein coding gene Chr15:36164349-36225437 (+)
C3H/HeJ ENSMUSGG00175054789
 protein coding gene Chr15:36348963-36408110 (+)
C57BL/6NJ ENSMUSGG00215055526
 protein coding gene Chr15:36165633-36226721 (+)
C57BL/6NJ ENSMUSG00215018882
 protein coding gene Chr15:36433793-36460827 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019758
 protein coding gene Chr15:33915935-34398307 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210017661
 protein coding gene Chr15:36554760-36581797 (+)
CBA/J ENSMUSGG00210055034
 protein coding gene Chr15:36286587-36347671 (+)
DBA/2J ENSMUSGG00185057742
 protein coding gene Chr15:36267391-36328476 (+)
DBA/2J ENSMUSG00185031165
 protein coding gene Chr15:36535587-36562620 (+)
FVB/NJ ENSMUSG00205021081
 protein coding gene Chr15:36419431-36446470 (+)
FVB/NJ ENSMUSGG00205054373
 protein coding gene Chr15:36153191-36212324 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055624
 protein coding gene Chr15:39627792-39686957 (+)
NOD/ShiLtJ ENSMUSG00190025379
 protein coding gene Chr15:36493760-36520795 (+)
NOD/ShiLtJ ENSMUSGG00190054630
 protein coding gene Chr15:36227544-36286675 (+)
NZO/HlLtJ ENSMUSGG00225055398
 protein coding gene Chr15:39945653-40006741 (+)
NZO/HlLtJ ENSMUSG00225030905
 protein coding gene Chr15:40213855-40240888 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010012222
 protein coding gene Chr15:36778874-37285666 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    RIMS2, regulating synaptic membrane exocytosis 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RIMS2, regulating synaptic membrane exocytosis 2
  • Synonyms
    CRSDS, OBOE, RAB3IP3, RIM2
  • Links
    NCBI Gene ID: 9699
    UniProt: Q9UQ26

  • Chr Location
    8q22.3; chr8:103500610-104256094 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show reduced body size, aberrant insulin granule exocytosis, and impaired secretion of hormones associated with glucose homeostasis. Mice homozygous for another knock-out allele show a slightly reduced body size, abnormal maternal behavior and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    626
  • Tissues
    9
  • cDNA Data
    4
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 116838 NCBI Gene Model | MGI Sequence Detail 486088 C57BL/6J ±  kb
    transcript NM_001256382 RefSeq | MGI Sequence Detail 7404 ZRU/MplStud  
    polypeptide Q9EQZ7 UniProt | EBI | MGI Sequence Detail 1530 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 7
      Primer pair 6

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36375, MGI:107798, MGI:1919910, MGI:2146180
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 7
      Gene Ontology 20
      Phenotypes 48
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:389879 Emperador-Melero J, et al., Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release. Elife. 2026 Jun 17;14
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory