Colec12 MGI Mouse Gene Detail - MGI:2152907 - collectin sub-family member 12

Symbol

Colec12
Name

collectin sub-family member 12
Synonyms

CL-P1, Scara4, SRCL

Feature Type

protein coding gene
IDs

MGI:2152907
NCBI Gene: 140792
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr18:9707648-9877995 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 4.91 cM
Mapping Data

1 experiment

SNPs within 2kb

4461 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2152907	protein coding gene	Chr18:9707595-9882644 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024142	protein coding gene	Chr18:6622310-6812056 (+)
A/J	MGP_AJ_G0024104	protein coding gene	Chr18:6589605-6758757 (+)
AKR/J	MGP_AKRJ_G0024071	protein coding gene	Chr18:6751450-6927464 (+)
BALB/cJ	MGP_BALBcJ_G0024103	protein coding gene	Chr18:6564078-6741019 (+)
C3H/HeJ	MGP_C3HHeJ_G0023870	protein coding gene	Chr18:6642772-6820764 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024548	protein coding gene	Chr18:7030978-7209409 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021987	protein coding gene	Chr18:6134467-6308059 (+)
CAST/EiJ	MGP_CASTEiJ_G0023347	protein coding gene	Chr18:6602458-6776186 (+)
CBA/J	MGP_CBAJ_G0023842	protein coding gene	Chr18:7031697-7230821 (+)
DBA/2J	MGP_DBA2J_G0023971	protein coding gene	Chr18:6437762-6612167 (+)
FVB/NJ	MGP_FVBNJ_G0023936	protein coding gene	Chr18:6398980-6573218 (+)
LP/J	MGP_LPJ_G0024054	protein coding gene	Chr18:6707350-6892189 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023965	protein coding gene	Chr18:7218678-7413913 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024594	protein coding gene	Chr18:6571347-6754295 (+)
PWK/PhJ	MGP_PWKPhJ_G0023092	protein coding gene	Chr18:6472452-6648932 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022903	protein coding gene	Chr18:6872706-7056719 (+)
WSB/EiJ	MGP_WSBEiJ_G0023413	protein coding gene	Chr18:6560468-6745275 (+)

Human Ortholog

COLEC12, collectin subfamily member 12

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COLEC12, collectin subfamily member 12
Synonyms

CLP1, NSR2, SCARA4, SRCL
Links

HGNC:16016

NCBI Gene ID: 81035

neXtProt AC: NX_Q5KU26

UniProt: Q5KU26
Chr Location

18p11.32; chr18:316737-500722 (-) GRCh38

MGI Vertebrate Homology

Colec12 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COLEC12
Gene Tree

Colec12

less

Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

22
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1120
Tissues

39
cDNA Data

49
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase colec12

ZFIN colec12

less

All Sequences

41
RefSeq

4
UniProt

2
CCDS

CCDS37732.1

Ensembl

ENSMUSG00000036103 (Evidence)
NCBI Gene

140792

			Length	Strain/Species	Flank
genomic	140792	NCBI Gene Model \| MGI Sequence Detail	170348	C57BL/6J	± kb
transcript	NM_130449	RefSeq \| MGI Sequence Detail	3322	C57BL/6
polypeptide	Q8K4Q8	UniProt \| EBI \| MGI Sequence Detail	742	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000005727 collectin-12

(term hierarchy)
PDB

2OX9
InterPro Domains

IPR033989 CD209-like, C-type lectin-like domain

IPR008160 Collagen triple helix repeat

IPR050111 C-type lectin and snaclec domain-containing protein

IPR018378 C-type lectin, conserved site

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

IPR052376 Oxidative Scavengers and Glycosyltransferases
GlyGen

Q8K4Q8 9 sites, 7 N-linked glycans (7 sites), 1 O-linked glycan (1 site)

less

All nucleic 52

cDNA 50

Primer pair 2

Microarray probesets 3

Summaries

All 37

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 7
Earliest

J:72785 Ohtani K, et al., The membrane-type collectin CL-P1 is a scavenger receptor on vascular endothelial cells. J Biol Chem. 2001 Nov 23;276(47):44222-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Colec12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150002	Chr18:9707612-9707638 (+)	-23 bp
Tssr150003	Chr18:9707639-9707661 (+)	2 bp
Tssr150004	Chr18:9722531-9722536 (+)	14,886 bp
Tssr150005	Chr18:9724734-9724745 (+)	17,092 bp
Tssr150006	Chr18:9728073-9728077 (+)	20,427 bp
Tssr150007	Chr18:9745193-9745207 (+)	37,552 bp
Tssr150008	Chr18:9745232-9745244 (+)	37,590 bp
Tssr150009	Chr18:9745325-9745333 (+)	37,681 bp
Tssr150010	Chr18:9745470-9745517 (+)	37,846 bp
Tssr150011	Chr18:9745539-9745583 (+)	37,913 bp
Tssr150012	Chr18:9746672-9746683 (+)	39,030 bp
Tssr150013	Chr18:9769968-9770017 (+)	62,345 bp
Tssr150014	Chr18:9781844-9781848 (+)	74,198 bp
Tssr150015	Chr18:9799143-9799178 (+)	91,513 bp
Tssr150016	Chr18:9848701-9848740 (+)	141,073 bp
Tssr150017	Chr18:9877165-9877180 (+)	169,525 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24