Helb MGI Mouse Gene Detail - MGI:2152895

Symbol

Helb
Name

helicase (DNA) B
Synonyms

D10Ertd664e

Feature Type

protein coding gene
IDs

MGI:2152895
NCBI Gene: 117599
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:119919513-119948892 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 67.94 cM
Mapping Data

3 experiments

SNPs within 2kb

194 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2152895	protein coding gene	Chr10:119919513-119948917 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017771	protein coding gene	Chr10:123213747-123246986 (-)
A/J	MGP_AJ_G0017746	protein coding gene	Chr10:118344384-118374262 (-)
AKR/J	MGP_AKRJ_G0017709	protein coding gene	Chr10:121873156-121904289 (-)
BALB/cJ	MGP_BALBcJ_G0017710	protein coding gene	Chr10:118737000-118766246 (-)
C3H/HeJ	MGP_C3HHeJ_G0017534	protein coding gene	Chr10:122083281-122113560 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018165	protein coding gene	Chr10:127392342-127426318 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015846	protein coding gene	Chr10:112713038-112742657 (-)
CAST/EiJ	MGP_CASTEiJ_G0017095	protein coding gene	Chr10:122387849-122419685 (-)
CBA/J	MGP_CBAJ_G0017503	protein coding gene	Chr10:132577919-132618185 (-)
DBA/2J	MGP_DBA2J_G0017609	protein coding gene	Chr10:117480146-117509816 (-)
FVB/NJ	MGP_FVBNJ_G0017604	protein coding gene	Chr10:116467384-116498769 (-)
LP/J	MGP_LPJ_G0017683	protein coding gene	Chr10:123769231-123800682 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017633	protein coding gene	Chr10:135208373-135239946 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018206	protein coding gene	Chr10:121883133-121913409 (-)
PWK/PhJ	MGP_PWKPhJ_G0016879	protein coding gene	Chr10:117578478-117608704 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016670	protein coding gene	Chr10:120774964-120806197 (-)
WSB/EiJ	MGP_WSBEiJ_G0017155	protein coding gene	Chr10:122122713-122154526 (-)

Human Ortholog

HELB, DNA helicase B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HELB, DNA helicase B
Synonyms

DHB, hDHB
Links

HGNC:17196

NCBI Gene ID: 92797

neXtProt AC: NX_Q8NG08

UniProt: Q8NG08
Chr Location

12q14.3; chr12:66302493-66343643 (+) GRCh38

MGI Vertebrate Homology

Helb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HELB
Gene Tree

Helb

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

13
Targeted

1
Genomic Mutations

1 involving Helb
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

67 strains or lines available

Homozygous knockout MEFs display increased DNA end resection, resulting in increased level of single-strand DNA formation at double-strand DNA breaks.

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All GO Annotations

38
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

36

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase helb

ZFIN helb

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All Sequences

38
RefSeq

3
UniProt

2
CCDS

CCDS24203.1

Ensembl

ENSMUSG00000020228 (Evidence)
NCBI Gene

117599

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020228	Ensembl Gene Model \| MGI Sequence Detail	29380	C57BL/6J	± kb
transcript	ENSMUST00000020449	Ensembl \| MGI Sequence Detail	4554	Not Applicable
polypeptide	ENSMUSP00000020449	Ensembl \| MGI Sequence Detail	1074	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008506 DNA helicase B

(term hierarchy)
EC

3.6.4.12
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR027785 UvrD-like helicase C-terminal domain

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All nucleic 37

cDNA 36

Primer pair 1

Microarray probesets 3

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MGI:1289215, MGI:2143601

Summaries

All 42

Gene Ontology 9

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Helb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99530	Chr10:119948890-119948907 (-)	-7 bp
Tssr99529	Chr10:119948851-119948864 (-)	34 bp
Tssr99528	Chr10:119948818-119948850 (-)	58 bp
Tssr99527	Chr10:119948770-119948816 (-)	99 bp
Tssr99526	Chr10:119928601-119928649 (-)	20,267 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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