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Gsk3a Gene Detail
Summary
  • Symbol
    Gsk3a
  • Name
    glycogen synthase kinase 3 alpha
  • Synonyms
    2700086H06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152453
    NCBI Gene: 606496
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24927683-24937276 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 13.73 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    217 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152453
 protein coding gene Chr7:24927683-24937276 (-)
129S1/SvImJ ENSMUSG00200040090
 protein coding gene Chr7:14931826-14941402 (-)
A/J ENSMUSG00195048615
 protein coding gene Chr7:17368579-17378173 (-)
AKR/J ENSMUSG00220051941
 protein coding gene Chr7:27012410-27022003 (+)
BALB/cJ ENSMUSG00180052132
 protein coding gene Chr7:15440548-15450141 (-)
C3H/HeJ ENSMUSG00175041569
 protein coding gene Chr7:16484678-16494271 (-)
C57BL/6NJ ENSMUSG00215054733
 protein coding gene Chr7:14844507-14854101 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029360
 protein coding gene Chr7:24495688-24505646 (-)
CAST/EiJ ENSTCUG00005048480
 protein coding gene Chr7:16539384-16548964 (-)
CBA/J ENSMUSG00210053079
 protein coding gene Chr7:15670397-15679990 (-)
DBA/2J ENSMUSG00185054010
 protein coding gene Chr7:18884151-18893744 (-)
FVB/NJ ENSMUSG00205023925
 protein coding gene Chr7:15680990-15690583 (-)
JF1/MsJ ENSUMUG00000055006
 protein coding gene Chr7:23179984-23189556 (-)
LP/J ENSMUSG00230052217
 protein coding gene Chr7:24157988-24167564 (-)
NOD/ShiLtJ ENSMUSG00190030412
 protein coding gene Chr7:15151296-15160889 (-)
NZO/HlLtJ ENSMUSG00225026784
 protein coding gene Chr7:22826154-22835747 (-)
PWK/PhJ ENSLUMG00010044212
 protein coding gene Chr7:15113838-15123410 (-)
SPRET/EiJ ENSMSPG00010050240
 protein coding gene Chr7:14779854-14789421 (-)
WSB/EiJ ENSIUOG00005050656
 protein coding gene Chr7:9646483-9656068 (-)



Homology
more
  • Human Ortholog
    GSK3A, glycogen synthase kinase 3 alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSK3A, glycogen synthase kinase 3 alpha
  • Links
    NCBI Gene ID: 2931
    UniProt: P49840

  • Chr Location
    19q13.2; chr19:42226225-42242625 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GSK3A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 6 alleles in 7 genetic backgrounds
    18 phenotypes from multigenic genotypes
    117 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit improved glucose tolerance, increased insulin sensitivity, decreased fat mass and increased lean mass. Mice homozygous for another null allele exhibit male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    109
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    703
  • Tissues
    61
  • cDNA Data
    7
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 606496 NCBI Gene Model | MGI Sequence Detail 9594 C57BL/6J ±  kb
    transcript NM_001031667 RefSeq | MGI Sequence Detail 2276 C57BL/6  
    polypeptide Q2NL51 UniProt | EBI | MGI Sequence Detail 490 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 7
      Primer pair 1
      Other 1
      Antibodies 8

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:1924078
    References
    more
    • Summaries
      All 217
      Developmental Gene Expression 29
      Gene Ontology 21
      Phenotypes 117
    • Earliest
      J:319997 Hart MJ, et al., Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr Biol. 1998 May 7;8(10):573-81
    • Latest
      J:376315 Yang M, et al., Glycogen Synthase Kinase 3 Is Essential for Intestinal Cell Niche and Digestive Function. Biology (Basel). 2025 Nov 5;14(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory