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Man2a2 Gene Detail
Summary
  • Symbol
    Man2a2
  • Name
    mannosidase 2, alpha 2
  • Synonyms
    1700052O22Rik, 4931438M07Rik, alpha mannosidase IIx, MX
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150656
    NCBI Gene: 140481
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:79998845-80021123 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.65 cM, cytoband D2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    587 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2150656
 protein coding gene Chr7:79998843-80021222 (-)
129S1/SvImJ ENSMUSG00200033008
 protein coding gene Chr7:66815499-66837511 (-)
A/J ENSMUSG00195037265
 protein coding gene Chr7:71227710-71248762 (-)
AKR/J ENSMUSG00220034344
 protein coding gene Chr7:64769721-64790775 (-)
BALB/cJ ENSMUSG00180012728
 protein coding gene Chr7:67952818-67973874 (-)
C3H/HeJ ENSMUSG00175019920
 protein coding gene Chr7:68727586-68749599 (-)
C57BL/6NJ ENSMUSG00215020869
 protein coding gene Chr7:67824691-67845760 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029904
 protein coding gene Chr7:82912155-82934085 (-)
CAST/EiJ ENSTCUG00005045190
 protein coding gene Chr7:71273911-71295958 (-)
CBA/J ENSMUSG00210023380
 protein coding gene Chr7:68578819-68600831 (-)
DBA/2J ENSMUSG00185042463
 protein coding gene Chr7:72901619-72923631 (-)
FVB/NJ ENSMUSG00205024712
 protein coding gene Chr7:68460890-68481945 (-)
JF1/MsJ ENSUMUG00000011010
 protein coding gene Chr7:77561045-77583147 (-)
LP/J ENSMUSG00230012512
 protein coding gene Chr7:78991100-79013111 (-)
NOD/ShiLtJ ENSMUSG00190017297
 protein coding gene Chr7:68719036-68740828 (-)
NZO/HlLtJ ENSMUSG00225041690
 protein coding gene Chr7:77229778-77250829 (-)
PWK/PhJ ENSLUMG00010017152
 protein coding gene Chr7:67152706-67174785 (-)
SPRET/EiJ ENSMSPG00010022991
 protein coding gene Chr7:67559921-67581850 (-)
WSB/EiJ ENSIUOG00005018691
 protein coding gene Chr7:69066628-69087672 (-)



Homology
more
  • Human Ortholog
    MAN2A2, mannosidase alpha class 2A member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAN2A2, mannosidase alpha class 2A member 2
  • Synonyms
    alpha-MIIx, MANA2X
  • Links
    NCBI Gene ID: 4122
    UniProt: P49641

  • Chr Location
    15q26.1; chr15:90902218-90922585 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null males are infertile due to a defect during spermatogenesis involving the premature release of germ cells from the seminiferous tubules into the epididymis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    794
  • Tissues
    99
  • cDNA Data
    11
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038886 Ensembl Gene Model | MGI Sequence Detail 22279 C57BL/6J ±  kb
    transcript ENSMUST00000098346 Ensembl | MGI Sequence Detail 6554 Not Applicable  
    polypeptide ENSMUSP00000095949 Ensembl | MGI Sequence Detail 1152 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000010106 alpha-mannosidase 2x
      (term hierarchy)
    • EC
      3.2.1.-, 3.2.1.114
    • InterPro Domains
      IPR011013 Galactose mutarotase-like domain superfamily
      IPR027291 Glycoside hydrolase 38, N-terminal domain superfamily
      IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
      IPR028995 Glycoside hydrolase families 57/38, central domain superfamily
      IPR015341 Glycoside hydrolase family 38, central domain
      IPR037094 Glycoside hydrolase family 38, central domain superfamily
      IPR000602 Glycoside hydrolase family 38, N-terminal domain
      IPR013780 Glycosyl hydrolase, all-beta
      IPR050843 Glycosyl Hydrolase Family 38
      IPR011682 Glycosyl hydrolase family 38, C-terminal
    • GlyGen
      Q8BRK9 3 sites, 1 N-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1920604, MGI:2141983, MGI:2444118
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory