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Dcun1d1 Gene Detail
Summary
  • Symbol
    Dcun1d1
  • Name
    defective in cullin neddylation 1 domain containing 1
  • Synonyms
    DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae), pTes3, Rp42, SCCRO, Tes3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150386
    NCBI Gene: 114893
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:35946254-35991594 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 17.41 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1041 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2150386
 protein coding gene Chr3:35946254-35991626 (-)
129S1/SvImJ ENSMUSG00200005959
 protein coding gene Chr3:32671481-32716090 (-)
A/J ENSMUSG00195001374
 protein coding gene Chr3:32665811-32710705 (-)
AKR/J ENSMUSG00220000416
 protein coding gene Chr3:32698486-32743090 (-)
BALB/cJ ENSMUSG00180002506
 protein coding gene Chr3:32799898-32845248 (-)
C3H/HeJ ENSMUSG00175003157
 protein coding gene Chr3:32695929-32740819 (-)
C57BL/6NJ ENSMUSG00215001408
 protein coding gene Chr3:33073919-33119264 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024931
 protein coding gene Chr3:30749163-30792867 (-)
CAST/EiJ ENSTCUG00005000743
 protein coding gene Chr3:32535221-32580136 (-)
CBA/J ENSMUSG00210001319
 protein coding gene Chr3:32744117-32789009 (-)
DBA/2J ENSMUSG00185001007
 protein coding gene Chr3:32944777-32990119 (-)
FVB/NJ ENSMUSG00205000536
 protein coding gene Chr3:32089880-32134435 (-)
JF1/MsJ ENSUMUG00000000441
 protein coding gene Chr3:32484546-32529093 (-)
LP/J ENSMUSG00230020697
 protein coding gene Chr3:34914449-34959051 (-)
NOD/ShiLtJ ENSMUSG00190001156
 protein coding gene Chr3:32989185-33034514 (-)
NZO/HlLtJ ENSMUSG00225006171
 protein coding gene Chr3:37538556-37583199 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005012902
 protein coding gene Chr3:32985436-33030061 (-)



Homology
more
  • Human Ortholog
    DCUN1D1, defective in cullin neddylation 1 domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCUN1D1, defective in cullin neddylation 1 domain containing 1
  • Synonyms
    DCNL1, DCUN1L1, RP42, SCCRO, SCRO, Tes3
  • Links
    NCBI Gene ID: 54165
    UniProt: Q96GG9

  • Chr Location
    3q26.33; chr3:182938074-182985953 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are runted with spleen and lymphoid hypoplasia and decreased mouse embryonic fibroblast proliferation. Males are infertile and exhibit abnormal spermiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    665
  • Tissues
    50
  • cDNA Data
    17
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027708 Ensembl Gene Model | MGI Sequence Detail 45341 C57BL/6J ±  kb
    transcript ENSMUST00000108182 Ensembl | MGI Sequence Detail 4980 Not Applicable  
    polypeptide ENSMUSP00000103817 Ensembl | MGI Sequence Detail 259 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 18
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1858962, MGI:2140091
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory