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Nexmif Gene Detail
Summary
  • Symbol
    Nexmif
  • Name
    neurite extension and migration factor
  • Synonyms
    C77370, Xpn
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148050
    NCBI Gene: 245555
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:103121040-103244791 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 46.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1947 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148050
 protein coding gene ChrX:103120367-103245403 (-)
129S1/SvImJ ENSMUSG00200037510
 protein coding gene ChrX:84882632-85006389 (-)
A/J ENSMUSG00195039890
 protein coding gene ChrX:88642568-88769083 (-)
AKR/J ENSMUSG00220037294
 protein coding gene ChrX:83309574-83433373 (-)
BALB/cJ ENSMUSG00180040272
 protein coding gene ChrX:85314684-85438440 (-)
C3H/HeJ ENSMUSG00175037892
 protein coding gene ChrX:88887479-89011236 (-)
C57BL/6NJ ENSMUSG00215046089
 protein coding gene ChrX:85499103-85621004 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033314
 protein coding gene ChrX:98272969-98382827 (-)
CAST/EiJ ENSTCUG00005040615
 protein coding gene ChrX:86357556-86475071 (-)
CBA/J ENSMUSG00210041098
 protein coding gene ChrX:85778289-85902040 (-)
DBA/2J ENSMUSG00185042802
 protein coding gene ChrX:98222055-98345856 (-)
FVB/NJ ENSMUSG00205032089
 protein coding gene ChrX:84849535-84968717 (-)
JF1/MsJ ENSUMUG00000018686
 protein coding gene ChrX:118825149-118942802 (-)
LP/J ENSMUSG00230039946
 protein coding gene ChrX:104915799-105039552 (-)
NOD/ShiLtJ ENSMUSG00190028972
 protein coding gene ChrX:84947035-85077153 (-)
NZO/HlLtJ ENSMUSG00225044948
 protein coding gene ChrX:110042974-110160328 (-)
PWK/PhJ ENSLUMG00010036720
 protein coding gene ChrX:84147557-84266816 (-)
SPRET/EiJ ENSMSPG00010036581
 protein coding gene ChrX:88343891-88464943 (-)
WSB/EiJ ENSIUOG00005040711
 protein coding gene ChrX:85446446-85563793 (-)



Homology
more
  • Human Ortholog
    NEXMIF, neurite extension and migration factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEXMIF, neurite extension and migration factor
  • Synonyms
    KIAA2022, KIDLIA, MRX98, XLID98, XPN
  • Links
    NCBI Gene ID: 340533
    UniProt: Q5QGS0

  • Chr Location
    Xq13.3; chrX:74732856-74925472 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Nexmif mouse models; 1 with human NEXMIF associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    46 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous for a knock-out allele show seizures, autism-like behaviors including reduced sociability, repetitive self-grooming, hyperactivity, decreased vocalization and deficits in spatial and fear memory, as well as a reduction in dendritic spine density and synaptic transmission.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    919
  • Tissues
    128
  • cDNA Data
    20
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046449 Ensembl Gene Model | MGI Sequence Detail 123752 C57BL/6J ±  kb
    transcript ENSMUST00000087879 Ensembl | MGI Sequence Detail 10891 Not Applicable  
    polypeptide ENSMUSP00000085187 Ensembl | MGI Sequence Detail 1515 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000059817 neurite extension and migration factor
      (term hierarchy)
    • InterPro Domains
      IPR032757 Domain of unknown function DUF4683
      IPR042794 Neurite extension and migration factor
    • GlyGen
      Q5DTT1 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 20
      Primer pair 4
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2148051, MGI:5908191
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory