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Aldh3b2 Gene Detail
Summary
  • Symbol
    Aldh3b2
  • Name
    aldehyde dehydrogenase 3 family, member B2
  • Synonyms
    C130048D07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147613
    NCBI Gene: 621603
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4022328-4031646 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147613
 protein coding gene Chr19:4022328-4031665 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0024603
 protein coding gene Chr19:750013-759016 (+)
AKR/J MGP_AKRJ_G0024574
 protein coding gene Chr19:776841-790510 (+)
BALB/cJ MGP_BALBcJ_G0024601
 protein coding gene Chr19:760585-771709 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0025049
 protein coding gene Chr19:797757-808993 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022478
 protein coding gene Chr19:715307-724646 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0024340
 protein coding gene Chr19:874686-886582 (+)
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0024555
 protein coding gene Chr19:781550-795382 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024466
 protein coding gene Chr19:826715-844557 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025097
 protein coding gene Chr19:768834-778921 (+)
PWK/PhJ MGP_PWKPhJ_G0023588
 protein coding gene Chr19:766098-775622 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023389
 protein coding gene Chr19:665760-667973 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ALDH3B2, aldehyde dehydrogenase 3 family member B2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALDH3B2, aldehyde dehydrogenase 3 family member B2
  • Synonyms
    ALDH8
  • Links
    NCBI Gene ID: 222
    UniProt: P48448

  • Chr Location
    11q13.2; chr11:67662155-67681252 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    2 phenotype references
Mice homozygous for a null allele exhibit postnatal lethality by P2 associated with impaired skin barrier function and reduced acylceramide levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    97
  • cDNA Data
    15
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000075296 Ensembl Gene Model | MGI Sequence Detail 9319 C57BL/6J ±  kb
transcript ENSMUST00000143380 Ensembl | MGI Sequence Detail 2142 Not Applicable  
polypeptide ENSMUSP00000115356 Ensembl | MGI Sequence Detail 479 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • EC
    1.2.1.3
  • InterPro Domains
    IPR016163 Aldehyde dehydrogenase, C-terminal
    IPR016160 Aldehyde dehydrogenase, cysteine active site
    IPR015590 Aldehyde dehydrogenase domain
    IPR029510 Aldehyde dehydrogenase, glutamic acid active site
    IPR012394 Aldehyde dehydrogenase NAD(P)-dependent
    IPR016162 Aldehyde dehydrogenase, N-terminal
    IPR016161 Aldehyde/histidinol dehydrogenase
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 6
    Phenotypes 2
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:330263 Nojiri K, et al., Impaired Skin Barrier Function Due to Reduced omega-O-Acylceramide Levels in a Mouse Model of Sjogren-Larsson Syndrome. Mol Cell Biol. 2021;41(10):e0035221
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory