Aldh3b2 MGI Mouse Gene Detail - MGI:2147613 - aldehyde dehydrogenase 3 family, member B2

Symbol

Aldh3b2
Name

aldehyde dehydrogenase 3 family, member B2
Synonyms

C130048D07Rik

Feature Type

protein coding gene
IDs

MGI:2147613
NCBI Gene: 621603
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:4022328-4031646 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 3.69 cM
Mapping Data

2 experiments

SNPs within 2kb

248 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2147613	protein coding gene	Chr19:4022328-4031665 (+)
129S1/SvImJ	ENSMUSG00200051103	protein coding gene	Chr19:782801-792113 (+)
A/J	ENSMUSG00195051606	protein coding gene	Chr19:1174093-1183411 (+)
AKR/J	ENSMUSG00220037082	protein coding gene	Chr19:947067-956385 (+)
BALB/cJ	ENSMUSG00180040254	protein coding gene	Chr19:1548840-1558158 (+)
C3H/HeJ	ENSMUSG00175008705	protein coding gene	Chr19:793589-802905 (+)
C57BL/6NJ	ENSMUSG00215035019	protein coding gene	Chr19:1021075-1030397 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022478	protein coding gene	Chr19:715307-724646 (+)
CAST/EiJ	ENSTCUG00005041082	protein coding gene	Chr19:935180-944312 (+)
CBA/J	ENSMUSG00210044453	protein coding gene	Chr19:793935-803253 (+)
DBA/2J	ENSMUSG00185047051	protein coding gene	Chr19:1170247-1179561 (+)
FVB/NJ	ENSMUSG00205028051	protein coding gene	Chr19:1177439-1186762 (+)
JF1/MsJ	ENSUMUG00000044900	protein coding gene	Chr19:1159096-1168380 (+)
LP/J	ENSMUSG00230054094	protein coding gene	Chr19:2088973-2098291 (+)
NOD/ShiLtJ	ENSMUSG00190023055	protein coding gene	Chr19:715223-724539 (+)
NZO/HlLtJ	ENSMUSG00225025226	protein coding gene	Chr19:5797807-5807125 (+)
PWK/PhJ	ENSLUMG00010003909	protein coding gene	Chr19:928792-938088 (+)
SPRET/EiJ	ENSMSPG00010034309	protein coding gene	Chr19:910306-919632 (+)
WSB/EiJ	ENSIUOG00005046577	protein coding gene	Chr19:800246-809562 (+)

Human Ortholog

ALDH3B2, aldehyde dehydrogenase 3 family member B2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALDH3B2, aldehyde dehydrogenase 3 family member B2
Synonyms

ALDH8
Links

HGNC:411

NCBI Gene ID: 222

UniProt: P48448
Chr Location

11q13.2; chr11:67662155-67681252 (-) GRCh38

MGI Vertebrate Homology

Aldh3b2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ALDH3B2
Protein SuperFamily

ALDH
Gene Tree

Aldh3b2

less

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotypes from multigenic genotypes
4 phenotype references

All Mutations and Alleles

2
Endonuclease-mediated

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available

Mice homozygous for a null allele exhibit postnatal lethality by P2 associated with impaired skin barrier function and reduced acylceramide levels.

less

All GO Annotations

18
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

698
Tissues

97
cDNA Data

15
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase aldh3b1

less

All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS50347.1

Ensembl

ENSMUSG00000075296 (Evidence)
NCBI Gene

621603

			Length	Strain/Species	Flank
genomic	ENSMUSG00000075296	Ensembl Gene Model \| MGI Sequence Detail	9319	C57BL/6J	± kb
transcript	ENSMUST00000143380	Ensembl \| MGI Sequence Detail	2142	Not Applicable
polypeptide	ENSMUSP00000115356	Ensembl \| MGI Sequence Detail	479	Not Applicable

less

UniProt

1 Sequence
EC

1.2.1.3, 1.2.1.48
InterPro Domains

IPR016163 Aldehyde dehydrogenase, C-terminal

IPR016160 Aldehyde dehydrogenase, cysteine active site

IPR015590 Aldehyde dehydrogenase domain

IPR029510 Aldehyde dehydrogenase, glutamic acid active site

IPR012394 Aldehyde dehydrogenase NAD(P)-dependent

IPR016162 Aldehyde dehydrogenase, N-terminal

IPR016161 Aldehyde/histidinol dehydrogenase

less

All nucleic 15

cDNA 15

Microarray probesets 3

Summaries

All 35

Developmental Gene Expression 4

Diseases 1

Gene Ontology 9

Phenotypes 4
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:390780 Qasrawi F, et al., DeltaNP63 regulates epithelial stratification and differentiation in the murine ureter. Am J Physiol Renal Physiol. 2026 Aug 1;331(2):F286-F303

TSS for Aldh3b2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154239	Chr19:4022322-4022345 (+)	6 bp
Tssr154240	Chr19:4022423-4022433 (+)	100 bp
Tssr154241	Chr19:4022437-4022468 (+)	125 bp
Tssr154242	Chr19:4022475-4022503 (+)	161 bp
Tssr154243	Chr19:4022507-4022566 (+)	209 bp
Tssr154244	Chr19:4029984-4030016 (+)	7,672 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24