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Slc39a6 Gene Detail
Summary
  • Symbol
    Slc39a6
  • Name
    solute carrier family 39 (metal ion transporter), member 6
  • Synonyms
    Ermelin, Zip6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147279
    NCBI Gene: 106957
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:24712938-24736874 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 13.18 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    643 from dbSNP Build 142
  • Strain Annotations
    26
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147279
 protein coding gene Chr18:24712938-24736874 (-)
129S1/SvImJ ENSMUSG00200015936
 protein coding gene Chr18:21731983-21732137 (-)
129S1/SvImJ ENSMUSGG00200054764
 protein coding gene Chr18:21712806-21729911 (-)
A/J ENSMUSGG00195055398
 protein coding gene Chr18:21870619-21887731 (-)
A/J ENSMUSG00195002053
 protein coding gene Chr18:21889785-21889939 (-)
AKR/J ENSMUSG00220010811
 protein coding gene Chr18:21886032-21886186 (-)
AKR/J ENSMUSGG00220054329
 protein coding gene Chr18:21866855-21883960 (-)
BALB/cJ ENSMUSG00180003224
 protein coding gene Chr18:22339890-22340044 (-)
BALB/cJ ENSMUSGG00180055482
 protein coding gene Chr18:22320711-22337818 (-)
C3H/HeJ ENSMUSGG00175054672
 protein coding gene Chr18:21834502-21851612 (-)
C3H/HeJ ENSMUSG00175023526
 protein coding gene Chr18:21853666-21853820 (-)
C57BL/6NJ ENSMUSG00215018969
 protein coding gene Chr18:21591664-21591818 (-)
C57BL/6NJ ENSMUSGG00215055509
 protein coding gene Chr18:21572487-21589592 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022051
 protein coding gene Chr18:21563541-21588416 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210015970
 protein coding gene Chr18:21880788-21880942 (-)
CBA/J ENSMUSGG00210054898
 protein coding gene Chr18:21861619-21878734 (-)
DBA/2J ENSMUSG00185021672
 protein coding gene Chr18:21828804-21828958 (-)
DBA/2J ENSMUSGG00185057323
 protein coding gene Chr18:21809636-21826750 (-)
FVB/NJ ENSMUSG00205018342
 protein coding gene Chr18:21561092-21561246 (-)
FVB/NJ ENSMUSGG00205054536
 protein coding gene Chr18:21541914-21559020 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055703
 protein coding gene Chr18:23908681-23925786 (-)
LP/J ENSMUSG00230005220
 protein coding gene Chr18:23927858-23928012 (-)
NOD/ShiLtJ ENSMUSG00190006820
 protein coding gene Chr18:21640513-21640667 (-)
NOD/ShiLtJ ENSMUSGG00190054819
 protein coding gene Chr18:21621345-21638459 (-)
NZO/HlLtJ ENSMUSGG00225055513
 protein coding gene Chr18:23857780-23874892 (-)
NZO/HlLtJ ENSMUSG00225025447
 protein coding gene Chr18:23876946-23877100 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SLC39A6, solute carrier family 39 member 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC39A6, solute carrier family 39 member 6
  • Synonyms
    LIV-1, LIV1, ZIP6
  • Links
    NCBI Gene ID: 25800
    UniProt: Q13433

  • Chr Location
    18q12.2; chr18:36108531-36129385 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Mice homozygous for a null allele do not display any gross skin abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    614
  • Tissues
    12
  • cDNA Data
    79
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 106957 NCBI Gene Model | MGI Sequence Detail 23937 C57BL/6J ±  kb
transcript NM_139143 RefSeq | MGI Sequence Detail 3905 C57BL/6  
polypeptide Q8C145 UniProt | EBI | MGI Sequence Detail 765 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 81
    cDNA 79
    Primer pair 2
    Antibodies 1

    Microarray probesets 4
References
more
  • Summaries
    All 47
    Developmental Gene Expression 4
    Gene Ontology 13
    Phenotypes 14
  • Earliest
    J:75677 Suzuki A, et al., Ermelin, an endoplasmic reticulum transmembrane protein, contains the novel HELP domain conserved in eukaryotes. Gene. 2002 Feb 6;284(1-2):31-40
  • Latest
    J:386398 Kageyama A, et al., The oocyte zinc transporter Slc39a10/Zip10 is a regulator of zinc sparks during fertilization in mice. Elife. 2025 Dec 11;14
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory