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Afap1l1 Gene Detail
Summary
  • Symbol
    Afap1l1
  • Name
    actin filament associated protein 1-like 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147199
    NCBI Gene: 106877
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:61863333-61919733 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 34.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    477 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147199
 protein coding gene Chr18:61863332-61919773 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024485
 protein coding gene Chr18:61633589-61693782 (-)
A/J MGP_AJ_G0024452
 protein coding gene Chr18:58987631-59044632 (-)
AKR/J MGP_AKRJ_G0024422
 protein coding gene Chr18:60608961-60670797 (-)
BALB/cJ MGP_BALBcJ_G0024451
 protein coding gene Chr18:59115312-59171417 (-)
C3H/HeJ MGP_C3HHeJ_G0024219
 protein coding gene Chr18:60843418-60906331 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024898
 protein coding gene Chr18:63304258-63367538 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022329
 protein coding gene Chr18:58531248-58584957 (-)
CAST/EiJ MGP_CASTEiJ_G0023692
 protein coding gene Chr18:60726574-60787309 (-)
CBA/J MGP_CBAJ_G0024189
 protein coding gene Chr18:65359219-65422398 (-)
DBA/2J MGP_DBA2J_G0024319
 protein coding gene Chr18:58657758-58714777 (-)
FVB/NJ MGP_FVBNJ_G0024285
 protein coding gene Chr18:58072000-58129398 (-)
LP/J MGP_LPJ_G0024402
 protein coding gene Chr18:61493115-61555102 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024314
 protein coding gene Chr18:66924949-66989683 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024945
 protein coding gene Chr18:60823050-60882724 (-)
PWK/PhJ MGP_PWKPhJ_G0023435
 protein coding gene Chr18:58889114-58948699 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023241
 protein coding gene Chr18:61045310-61102009 (-)
WSB/EiJ MGP_WSBEiJ_G0023756
 protein coding gene Chr18:60674267-60738616 (-)



Homology
more
  • Human Ortholog
    AFAP1L1, actin filament associated protein 1 like 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AFAP1L1, actin filament associated protein 1 like 1
  • Links
    NCBI Gene ID: 134265
    neXtProt AC: NX_Q8TED9
    UniProt: Q8TED9

  • Chr Location
    5q32; chr5:149271859-149343637 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
DNA-templated transcription
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    6
  • cDNA Data
    37
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 106877 NCBI Gene Model | MGI Sequence Detail 56401 C57BL/6J ±  kb
transcript NM_178928 RefSeq | MGI Sequence Detail 3403 C57BL/6  
polypeptide Q8BZI0 UniProt | EBI | MGI Sequence Detail 768 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 37

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:325730 Ahuja N, et al., Endothelial Cyp26b1 restrains murine heart valve growth during development. Dev Biol. 2022 Jun;486:81-95
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/28/2023
MGI 6.22 		The Jackson Laboratory