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Ldhal6b Gene Detail
Summary
  • Symbol
    Ldhal6b
  • Name
    lactate dehydrogenase A-like 6B
  • Synonyms
    4933402O15Rik, LDHAL
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146830
    NCBI Gene: 106557
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:5467598-5469042 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 3.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    153 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146830
 protein coding gene Chr17:5467598-5469042 (-)
129S1/SvImJ ENSMUSG00200033053
 protein coding gene Chr17:2363298-2364742 (-)
A/J ENSMUSG00195021635
 protein coding gene Chr17:2357244-2358688 (-)
AKR/J ENSMUSG00220025133
 protein coding gene Chr17:2552697-2554141 (-)
BALB/cJ ENSMUSG00180023671
 protein coding gene Chr17:2369032-2370476 (-)
C3H/HeJ ENSMUSG00175030858
 protein coding gene Chr17:2329038-2330482 (-)
C57BL/6NJ ENSMUSG00215014668
 protein coding gene Chr17:2349892-2351336 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021023
 protein coding gene Chr17:2315271-2316716 (-)
CAST/EiJ ENSTCUG00005021713
 protein coding gene Chr17:2391886-2393330 (-)
CBA/J ENSMUSG00210033610
 protein coding gene Chr17:2345997-2347441 (-)
DBA/2J ENSMUSG00185023460
 protein coding gene Chr17:2449217-2450661 (-)
FVB/NJ ENSMUSG00205008608
 protein coding gene Chr17:2404107-2405549 (-)
JF1/MsJ ENSUMUG00000021618
 protein coding gene Chr17:2429076-2430514 (-)
LP/J ENSMUSG00230032502
 protein coding gene Chr17:3546427-3547871 (-)
NOD/ShiLtJ ENSMUSG00190028721
 protein coding gene Chr17:2334944-2336382 (-)
NZO/HlLtJ ENSMUSG00225029064
 protein coding gene Chr17:5850410-5851854 (-)
PWK/PhJ ENSLUMG00010018849
 protein coding gene Chr17:2451977-2453421 (-)
SPRET/EiJ ENSMSPG00010035114
 protein coding gene Chr17:2376935-2378378 (-)
WSB/EiJ ENSIUOG00005013673
 protein coding gene Chr17:2397545-2398987 (-)



Homology
more
  • Human Ortholog
    LDHAL6A, lactate dehydrogenase A like 6A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LDHAL6A, lactate dehydrogenase A like 6A
  • Synonyms
    LDH6A
  • Links
    NCBI Gene ID: 160287
    UniProt: Q6ZMR3

  • Chr Location
    11p15.1; chr11:18455824-18479601 (+)  GRCh38
  • Human Ortholog
    LDHAL6B, lactate dehydrogenase A like 6B
  • Synonyms
    LDH6B, LDHAL6, LDHL
  • Links
    NCBI Gene ID: 92483
    UniProt: Q9BYZ2

  • Chr Location
    15q22.2; chr15:59206843-59208588 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males homozygous for a null allele show normal male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    7
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 106557 NCBI Gene Model | MGI Sequence Detail 1445 C57BL/6J ±  kb
transcript NM_175349 RefSeq | MGI Sequence Detail 1463 Not Specified  
polypeptide NP_780558 RefSeq | MGI Sequence Detail 382 Not Specified  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • EC
    1.1.1.27
  • InterPro Domains
    IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
    IPR022383 Lactate/malate dehydrogenase, C-terminal
    IPR001236 Lactate/malate dehydrogenase, N-terminal
    IPR011304 L-lactate dehydrogenase
    IPR018177 L-lactate dehydrogenase, active site
    IPR001557 L-lactate/malate dehydrogenase
    IPR036291 NAD(P)-binding domain superfamily
Molecular
Reagents
less
  • All nucleic 8
    cDNA 7
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:371359 Huang X, et al., Lactate dehydrogenase a-like 6B is not essential for spermatogenesis and male fertility in mice. Gene. 2025 Feb 5;936:149100
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory