Ubxn7 MGI Mouse Gene Detail - MGI:2146388

Symbol

Ubxn7
Name

UBX domain protein 7
Synonyms

mKIAA0794, Ubxd7

Feature Type

protein coding gene
IDs

MGI:2146388
NCBI Gene: 224111
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr16:32151075-32212565 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 22.58 cM
Mapping Data

1 experiment

SNPs within 2kb

952 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2146388	protein coding gene	Chr16:32151023-32212568 (+)
129S1/SvImJ	ENSMUSG00200035553	protein coding gene	Chr16:29171453-29233037 (+)
A/J	ENSMUSG00195027593	protein coding gene	Chr16:28712136-28773979 (+)
AKR/J	ENSMUSG00220030869	protein coding gene	Chr16:29004448-29066293 (+)
BALB/cJ	ENSMUSG00180026140	protein coding gene	Chr16:28927989-28989837 (+)
C3H/HeJ	ENSMUSG00175036218	protein coding gene	Chr16:29072940-29134526 (+)
C57BL/6NJ	ENSMUSG00215014338	protein coding gene	Chr16:28956230-29017826 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020670	protein coding gene	Chr16:29332381-29401425 (+)
CAST/EiJ	ENSTCUG00005034026	protein coding gene	Chr16:29341935-29405649 (+)
CBA/J	ENSMUSG00210031083	protein coding gene	Chr16:29114931-29176522 (+)
DBA/2J	ENSMUSG00185017548	protein coding gene	Chr16:29030413-29092011 (+)
FVB/NJ	ENSMUSG00205018362	protein coding gene	Chr16:29043649-29105489 (+)
JF1/MsJ	ENSUMUG00000020445	protein coding gene	Chr16:29209719-29271812 (+)
LP/J	ENSMUSG00230028537	protein coding gene	Chr16:31599185-31660777 (+)
NOD/ShiLtJ	ENSMUSG00190028853	protein coding gene	Chr16:29219767-29281405 (+)
NZO/HlLtJ	ENSMUSG00225039313	protein coding gene	Chr16:34832250-34893827 (+)
PWK/PhJ	ENSLUMG00010028667	protein coding gene	Chr16:29028342-29090439 (+)
SPRET/EiJ	ENSMSPG00010018071	protein coding gene	Chr16:29020818-29082853 (+)
WSB/EiJ	ENSIUOG00005031682	protein coding gene	Chr16:29198000-29259589 (+)

Human Ortholog

UBXN7, UBX domain protein 7

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBXN7, UBX domain protein 7
Synonyms

UBXD7
Links

HGNC:29119

NCBI Gene ID: 26043

UniProt: O94888
Chr Location

3q29; chr3:196347659-196432430 (-) GRCh38

MGI Vertebrate Homology

Ubxn7 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: UBXN7
Protein SuperFamily

UCP037991_UBX7/2
Gene Tree

Ubxn7

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Endonuclease-mediated

1
Gene trapped

31
Targeted

4
Genomic Mutations

1 involving Ubxn7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

47 strains or lines available

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

640
Tissues

33
cDNA Data

33
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ubxn7

ZFIN ubxn7

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All Sequences

51
RefSeq

10
UniProt

3
CCDS

CCDS49826.1

Ensembl

ENSMUSG00000053774 (Evidence)
NCBI Gene

224111

			Length	Strain/Species	Flank
genomic	ENSMUSG00000053774	Ensembl Gene Model \| MGI Sequence Detail	61491	C57BL/6J	± kb
transcript	ENSMUST00000115151	Ensembl \| MGI Sequence Detail	10313	Not Applicable
polypeptide	ENSMUSP00000110804	Ensembl \| MGI Sequence Detail	489	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030761 UBX domain-containing protein 7

(term hierarchy)
InterPro Domains

IPR012336 Thioredoxin-like fold

IPR036249 Thioredoxin-like superfamily

IPR006577 UAS

IPR054109 UBA-like domain

IPR009060 UBA-like superfamily

IPR029071 Ubiquitin-like domain superfamily

IPR001012 UBX domain

IPR050730 UBX domain-containing protein

IPR017346 UBX domain-containing protein 2/7
GlyGen

Q6P5G6 1 site, 1 O-linked glycan (1 site)

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All nucleic 35

cDNA 35

Microarray probesets 2

Summaries

All 39

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 14
Earliest

J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
Latest

J:363513 Chen H, et al., The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway. Cell Rep. 2025 Feb 25;44(2):115231

TSS for Ubxn7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137967	Chr16:32151056-32151084 (+)	-5 bp
Tssr137968	Chr16:32194782-32194813 (+)	43,723 bp
Tssr137969	Chr16:32198754-32198759 (+)	47,682 bp
Tssr137970	Chr16:32203916-32203931 (+)	52,849 bp
Tssr137971	Chr16:32207595-32207599 (+)	56,522 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24