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Amigo2 Gene Detail
Summary
  • Symbol
    Amigo2
  • Name
    adhesion molecule with Ig like domain 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145995
    NCBI Gene: 105827
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:97142006-97145168 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 52.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145995
protein coding gene Chr15:97141955-97145168 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022274
protein coding gene Chr15:98888508-98891755 (-)
A/J MGP_AJ_G0022233
protein coding gene Chr15:94985611-94988824 (-)
AKR/J MGP_AKRJ_G0022208
protein coding gene Chr15:97864200-97867414 (-)
BALB/cJ MGP_BALBcJ_G0022239
protein coding gene Chr15:95200885-95204098 (-)
C3H/HeJ MGP_C3HHeJ_G0022009
protein coding gene Chr15:97895352-97898565 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022684
protein coding gene Chr15:102531601-102534814 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020210
protein coding gene Chr15:90953789-90957009 (-)
CAST/EiJ MGP_CASTEiJ_G0021531
protein coding gene Chr15:98785642-98788856 (-)
CBA/J MGP_CBAJ_G0021976
protein coding gene Chr15:105973055-105976269 (-)
DBA/2J MGP_DBA2J_G0022103
protein coding gene Chr15:94429162-94432376 (-)
FVB/NJ MGP_FVBNJ_G0022082
protein coding gene Chr15:93423428-93426453 (-)
LP/J MGP_LPJ_G0022174
protein coding gene Chr15:98997993-99001200 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022102
protein coding gene Chr15:110120386-110123599 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022699
protein coding gene Chr15:97981465-97984680 (-)
PWK/PhJ MGP_PWKPhJ_G0021272
protein coding gene Chr15:94522268-94525431 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021106
protein coding gene Chr15:97776819-97780040 (-)
WSB/EiJ MGP_WSBEiJ_G0021580
protein coding gene Chr15:98506766-98509984 (-)



Homology
more
  • Human Ortholog
    AMIGO2, adhesion molecule with Ig like domain 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AMIGO2, adhesion molecule with Ig like domain 2
  • Synonyms
    ALI1, AMIGO-2, DEGA
  • Links
    NCBI Gene ID: 347902
    neXtProt AC: NX_Q86SJ2
    UniProt: Q86SJ2

  • Chr Location
    12q13.11; chr12:47075707-47079959 (-)  GRCh38

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit starburst amacrine cell and rod bipolar cell dendrite arbor expansion and enhanced direction selectivity of direction-selective ganglion cell responses to starburst amacrine cell signals.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048218 Ensembl Gene Model | MGI Sequence Detail 3163 C57BL/6J ±  kb
transcript ENSMUST00000229890 Ensembl | MGI Sequence Detail 2998 Not Applicable  
polypeptide ENSMUSP00000155019 Ensembl | MGI Sequence Detail 519 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 9
    Primer pair 2
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146206
References
more
  • Summaries
    All 60
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 6
    Phenotypes 27
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:347599 Raja R, et al., Insertion of a neomycin selection cassette in the Amigo1 locus alters gene expression in the olfactory epithelium leading to region-specific defects in olfactory receptor neuron development. Genesis. 2024 Apr;62(2):e23594

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory