Fam149b MGI Mouse Gene Detail - MGI:2145567 - family with sequence similarity 149, member B

Symbol

Fam149b
Name

family with sequence similarity 149, member B
Synonyms

MGC:32264, mKIAA0974

Feature Type

protein coding gene
IDs

MGI:2145567
NCBI Gene: 105428
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr14:20398230-20433559 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 11.52 cM
Mapping Data

1 experiment

SNPs within 2kb

1720 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145567	protein coding gene	Chr14:20398221-20433559 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021032	protein coding gene	Chr14:13094512-13134845 (+)
A/J	MGP_AJ_G0020981	protein coding gene	Chr14:12798549-12833947 (+)
AKR/J	MGP_AKRJ_G0020958	protein coding gene	Chr14:13321715-13358212 (+)
BALB/cJ	MGP_BALBcJ_G0020984	protein coding gene	Chr14:12907056-12942337 (+)
C3H/HeJ	MGP_C3HHeJ_G0020768	protein coding gene	Chr14:13257180-13294171 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021417	protein coding gene	Chr14:13598553-13633871 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018985	protein coding gene	Chr14:13107977-13143035 (+)
CAST/EiJ	MGP_CASTEiJ_G0020292	protein coding gene	Chr14:13023968-13059069 (+)
CBA/J	MGP_CBAJ_G0020734	protein coding gene	Chr14:14289533-14324780 (+)
DBA/2J	MGP_DBA2J_G0020857	protein coding gene	Chr14:12628645-12664074 (+)
FVB/NJ	MGP_FVBNJ_G0020840	protein coding gene	Chr14:12520470-12559503 (+)
LP/J	MGP_LPJ_G0020933	protein coding gene	Chr14:13315381-13352314 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020866	protein coding gene	Chr14:14065019-14101954 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021450	protein coding gene	Chr14:13109503-13145910 (+)
PWK/PhJ	MGP_PWKPhJ_G0020041	protein coding gene	Chr14:12189416-12225094 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019863	protein coding gene	Chr14:12883049-12921660 (+)
WSB/EiJ	MGP_WSBEiJ_G0020348	protein coding gene	Chr14:13093537-13129772 (+)

Human Ortholog

FAM149B1, family with sequence similarity 149 member B1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM149B1, family with sequence similarity 149 member B1
Synonyms

JBTS36, KIAA0974
Links

HGNC:29162

NCBI Gene ID: 317662

UniProt: Q96BN6
Chr Location

10q22.2; chr10:73168119-73244504 (+) GRCh38

MGI Vertebrate Homology

Fam149b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FAM149B1
Gene Tree

Fam149b

Diseases

1 with human FAM149B1 associations

				Human Disease	Mouse Models
				Joubert syndrome IDs Joubert syndrome DOID:0050777 ICD10CM:Q04.3 OMIM:PS213300 ORDO:475

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Gene trapped

5
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

20
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

140
RefSeq

63
UniProt

6
CCDS

CCDS49408.1, CCDS49409.1, CCDS49410.1

Ensembl

ENSMUSG00000039599 (Evidence)
NCBI Gene

105428

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039599	Ensembl Gene Model \| MGI Sequence Detail	35330	C57BL/6J	± kb
transcript	ENSMUST00000225942	Ensembl \| MGI Sequence Detail	2151	Not Applicable
polypeptide	ENSMUSP00000153645	Ensembl \| MGI Sequence Detail	606	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000030782 primary cilium assembly protein FAM149B1

(term hierarchy)
InterPro Domains

IPR022194 Domain of unknown function DUF3719

IPR039630 Protein FAM149

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All nucleic 20

cDNA 20

Microarray probesets 4

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MGI:2145636

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 6
Earliest

J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
Latest

J:181631 Gehman LT, et al., The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function. Genes Dev. 2012 Mar 1;26(5):445-60

TSS for Fam149b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124379	Chr14:20398227-20398312 (+)	40 bp
Tssr124380	Chr14:20398371-20398393 (+)	152 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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