Mis18bp1 MGI Mouse Gene Detail - MGI:2145099

Symbol

Mis18bp1
Name

MIS18 binding protein 1
Synonyms

C79407

Feature Type

protein coding gene
IDs

MGI:2145099
NCBI Gene: 217653
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:65179508-65219363 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 27.21 cM
Mapping Data

1 experiment

SNPs within 2kb

878 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145099	protein coding gene	Chr12:65179508-65219378 (-)
129S1/SvImJ	ENSMUSG00200003723	protein coding gene	Chr12:57133746-57173652 (-)
A/J	ENSMUSG00195001662	protein coding gene	Chr12:59762471-59804079 (-)
AKR/J	ENSMUSG00220015523	protein coding gene	Chr12:57858436-57898365 (-)
BALB/cJ	ENSMUSG00180007318	protein coding gene	Chr12:58776878-58818481 (-)
C3H/HeJ	ENSMUSG00175025954	protein coding gene	Chr12:61857969-61899571 (-)
C57BL/6NJ	ENSMUSG00215009086	protein coding gene	Chr12:58116495-58156428 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017792	protein coding gene	Chr12:60047728-60089618 (-)
CAST/EiJ	ENSTCUG00005012224	protein coding gene	Chr12:58153633-58193301 (-)
CBA/J	ENSMUSG00210014099	protein coding gene	Chr12:58323266-58364868 (-)
DBA/2J	ENSMUSG00185004728	protein coding gene	Chr12:60226817-60266750 (-)
FVB/NJ	ENSMUSG00205005463	protein coding gene	Chr12:58020672-58060613 (-)
JF1/MsJ	ENSUMUG00000016009	protein coding gene	Chr12:64237169-64277028 (-)
LP/J	ENSMUSG00230011043	protein coding gene	Chr12:67232935-67272849 (-)
NOD/ShiLtJ	ENSMUSG00190006752	protein coding gene	Chr12:57330573-57370487 (-)
NZO/HlLtJ	ENSMUSG00225029462	protein coding gene	Chr12:69300104-69340019 (-)
PWK/PhJ	ENSLUMG00010002470	protein coding gene	Chr12:58298497-58338331 (-)
SPRET/EiJ	ENSMSPG00010010765	protein coding gene	Chr12:59896986-59937168 (-)
WSB/EiJ	ENSIUOG00005000926	protein coding gene	Chr12:58022515-58064075 (-)

Human Ortholog

MIS18BP1, MIS18 binding protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIS18BP1, MIS18 binding protein 1
Synonyms

C14orf106, HSA242977, KNL2, M18BP1
Links

HGNC:20190

NCBI Gene ID: 55320

UniProt: Q6P0N0
Chr Location

14q21.2; chr14:45203190-45253542 (-) GRCh38

MGI Vertebrate Homology

Mis18bp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MIS18BP1
Gene Tree

Mis18bp1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

39
Chemically induced (other)

1
Gene trapped

35
Targeted

3
Genomic Mutations

1 involving Mis18bp1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

65 strains or lines available

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All GO Annotations

11
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
Tissues

5
cDNA Data

98
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mis18bp1

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All Sequences

64
RefSeq

8
UniProt

6
CCDS

CCDS25942.1

Ensembl

ENSMUSG00000047534 (Evidence)
NCBI Gene

217653

			Length	Strain/Species	Flank
genomic	217653	NCBI Gene Model \| MGI Sequence Detail	39856	C57BL/6J	± kb
transcript	NM_172578	RefSeq \| MGI Sequence Detail	4026	C57BL/6
polypeptide	Q80WQ8	UniProt \| EBI \| MGI Sequence Detail	998	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000010031 Mis18-binding protein 1

(term hierarchy)
InterPro Domains

IPR009057 Homeodomain-like superfamily

IPR039110 KNL2-like

IPR015216 SANT associated

IPR001005 SANT/Myb domain
GlyGen

Q80WQ8 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 98

cDNA 98

Microarray probesets 6

Summaries

All 46

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 13
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:366955 Thamkachy R, et al., Structural basis for Mis18 complex assembly and its implications for centromere maintenance. EMBO Rep. 2024 Aug;25(8):3348-3372

TSS for Mis18bp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116468	Chr12:65219334-65219392 (-)	0 bp
Tssr116467	Chr12:65219315-65219326 (-)	42 bp
Tssr116466	Chr12:65205977-65205979 (-)	13,385 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24