Cep170b MGI Mouse Gene Detail - MGI:2145043

Symbol

Cep170b
Name

centrosomal protein 170B
Synonyms

AW555464, mKIAA0284

Feature Type

protein coding gene
IDs

MGI:2145043
NCBI Gene: 217882
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr12:112687950-112713026 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 61.20 cM
Mapping Data

2 experiments

SNPs within 2kb

331 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145043	protein coding gene	Chr12:112686889-112713026 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020158	protein coding gene	Chr12:115193819-115218214 (+)
A/J	MGP_AJ_G0020114	protein coding gene	Chr12:110752442-110776936 (+)
AKR/J	MGP_AKRJ_G0020089	protein coding gene	Chr12:113946642-113974424 (+)
BALB/cJ	MGP_BALBcJ_G0020099	protein coding gene	Chr12:111196845-111221245 (+)
C3H/HeJ	MGP_C3HHeJ_G0019901	protein coding gene	Chr12:114454773-114479264 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020544	protein coding gene	Chr12:118757063-118783514 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018158	protein coding gene	Chr12:107182300-107206834 (+)
CAST/EiJ	MGP_CASTEiJ_G0019441	protein coding gene	Chr12:109303035-109327448 (+)
CBA/J	MGP_CBAJ_G0019868	protein coding gene	Chr12:123290756-123315247 (+)
DBA/2J	MGP_DBA2J_G0019985	protein coding gene	Chr12:110231379-110255792 (+)
FVB/NJ	MGP_FVBNJ_G0019970	protein coding gene	Chr12:109059174-109085587 (+)
LP/J	MGP_LPJ_G0020059	protein coding gene	Chr12:115024785-115049184 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020008	protein coding gene	Chr12:126374711-126402054 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020573	protein coding gene	Chr12:113470471-113494944 (+)
PWK/PhJ	MGP_PWKPhJ_G0019203	protein coding gene	Chr12:104891105-104915563 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019007	protein coding gene	Chr12:107631871-107656432 (+)
WSB/EiJ	MGP_WSBEiJ_G0019501	protein coding gene	Chr12:114377822-114402302 (+)

Human Ortholog

CEP170B, centrosomal protein 170B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CEP170B, centrosomal protein 170B
Synonyms

CEP170R, FAM68C, KIAA0284
Links

HGNC:20362

NCBI Gene ID: 283638

neXtProt AC: NX_Q9Y4F5

UniProt: Q9Y4F5
Chr Location

14q32.33; chr14:104864513-104896747 (+) GRCh38

Alliance of Genome Resources

Cep170b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CEP170B
Gene Tree

Cep170b

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Gene trapped

1
Targeted

2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

28 strains or lines available

less

All GO Annotations

3
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

823
Tissues

21
cDNA Data

97
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cep170b

ZFIN cep170bb

less

Cep170b interacts with 242 markers (Mir7-1, Mir9-1, Mir9-2, ...) View All

less

All Sequences

56
RefSeq

6
UniProt

3
CCDS

CCDS56867.1

Ensembl

ENSMUSG00000072825 (Evidence)
NCBI Gene

217882

			Length	Strain/Species	Flank
genomic	217882	NCBI Gene Model \| MGI Sequence Detail	25077	C57BL/6J	± kb
transcript	NM_001024602	RefSeq \| MGI Sequence Detail	6627	ZRU/MplStud
polypeptide	Q80U49	UniProt \| EBI \| MGI Sequence Detail	1574	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000060141 centrosomal protein of 170 kDa protein B

(term hierarchy)
InterPro Domains

IPR029300 CEP170, C-terminal

IPR000253 Forkhead-associated (FHA) domain

IPR008984 SMAD/FHA domain superfamily

less

All nucleic 97

cDNA 97

Microarray probesets 2

less

MGI:2445826

Summaries

All 28

Developmental Gene Expression 2

Gene Ontology 1

Phenotypes 6
Earliest

J:75291 Witherden AS, et al., An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the 'Legs at odd angles' (Loa) mutation. Gene. 2002 Jan 23;283(1-2):71-82
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Cep170b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115399	Chr12:112687539-112687561 (+)	-400 bp
Tssr115400	Chr12:112687938-112687964 (+)	1 bp
Tssr115401	Chr12:112688263-112688283 (+)	323 bp
Tssr115402	Chr12:112688597-112688673 (+)	685 bp
Tssr115403	Chr12:112688944-112688968 (+)	1,006 bp
Tssr115404	Chr12:112689229-112689255 (+)	1,292 bp
Tssr115405	Chr12:112697553-112697556 (+)	9,605 bp
Tssr115406	Chr12:112697643-112697652 (+)	9,698 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/19/2023 MGI 6.22