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Plekhh1 Gene Detail
Summary
  • Symbol
    Plekhh1
  • Name
    pleckstrin homology, MyTH4 and FERM domain containing H1
  • Synonyms
    D630024D12Rik, mKIAA1200
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144989
    NCBI Gene: 211945
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:79075937-79128429 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 35.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1447 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144989
 protein coding gene Chr12:79075937-79128429 (+)
129S1/SvImJ ENSMUSG00200045994
 protein coding gene Chr12:71039273-71091753 (+)
A/J ENSMUSG00195031711
 protein coding gene Chr12:73738439-73790927 (+)
AKR/J ENSMUSG00220046155
 protein coding gene Chr12:71525732-71575435 (+)
BALB/cJ ENSMUSG00180017086
 protein coding gene Chr12:72718410-72768110 (+)
C3H/HeJ ENSMUSG00175039603
 protein coding gene Chr12:75870841-75923329 (+)
C57BL/6NJ ENSMUSG00215044966
 protein coding gene Chr12:72075423-72127912 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017885
 protein coding gene Chr12:73482152-73534458 (+)
CAST/EiJ ENSTCUG00005028581
 protein coding gene Chr12:72010266-72059705 (+)
CBA/J ENSMUSG00210036414
 protein coding gene Chr12:72285179-72337667 (+)
DBA/2J ENSMUSG00185040135
 protein coding gene Chr12:74145822-74198314 (+)
FVB/NJ ENSMUSG00205028982
 protein coding gene Chr12:71887340-71939832 (+)
JF1/MsJ ENSUMUG00000010540
 protein coding gene Chr12:78131304-78180514 (+)
LP/J ENSMUSG00230021561
 protein coding gene Chr12:81157457-81209937 (+)
NOD/ShiLtJ ENSMUSG00190039504
 protein coding gene Chr12:71349998-71399710 (+)
NZO/HlLtJ ENSMUSG00225049896
 protein coding gene Chr12:83223771-83273471 (+)
PWK/PhJ ENSLUMG00010027943
 protein coding gene Chr12:72161101-72210211 (+)
SPRET/EiJ ENSMSPG00010016355
 protein coding gene Chr12:73986146-74035643 (+)
WSB/EiJ ENSIUOG00005039942
 protein coding gene Chr12:71971504-72021205 (+)



Homology
more
  • Human Ortholog
    PLEKHH1, pleckstrin homology, MyTH4 and FERM domain containing H1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHH1, pleckstrin homology, MyTH4 and FERM domain containing H1
  • Links
    NCBI Gene ID: 57475
    UniProt: Q9ULM0

  • Chr Location
    14q24.1; chr14:67533290-67589612 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    633
  • Tissues
    36
  • cDNA Data
    50
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 211945 NCBI Gene Model | MGI Sequence Detail 52493 C57BL/6J ±  kb
    transcript NM_181073 RefSeq | MGI Sequence Detail 6451 C57BL/6  
    polypeptide Q80TI1 UniProt | EBI | MGI Sequence Detail 1356 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 50

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145084
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 13
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:355142 Gomez-Del Arco P, et al., The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. Nat Commun. 2024 Oct 4;15(1):8602
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory