Ptpn23 MGI Mouse Gene Detail - MGI:2144837 - protein tyrosine phosphatase, non-receptor type 23

Symbol

Ptpn23
Name

protein tyrosine phosphatase, non-receptor type 23
Synonyms

PTP-TD14

Feature Type

protein coding gene
IDs

MGI:2144837
NCBI Gene: 104831
Alliance

genome feature page
Transcription Start Sites

11 TSS

Sequence Map

Chr9:110214152-110237278 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 59.92 cM
Mapping Data

1 experiment

SNPs within 2kb

594 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2144837	protein coding gene	Chr9:110214150-110237281 (-)
129S1/SvImJ	ENSMUSG00200041532	protein coding gene	Chr9:107307122-107330254 (-)
A/J	ENSMUSG00195042796	protein coding gene	Chr9:106600630-106623763 (-)
AKR/J	ENSMUSG00220022710	protein coding gene	Chr9:106936298-106959432 (-)
BALB/cJ	ENSMUSG00180030676	protein coding gene	Chr9:107055524-107078655 (-)
C3H/HeJ	ENSMUSG00175029125	protein coding gene	Chr9:107271367-107294498 (-)
C57BL/6NJ	ENSMUSG00215017694	protein coding gene	Chr9:107151351-107174481 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032730	protein coding gene	Chr9:105664290-105687522 (-)
CAST/EiJ	ENSTCUG00005026978	protein coding gene	Chr9:106962554-106985528 (-)
CBA/J	ENSMUSG00210031371	protein coding gene	Chr9:106988029-107011004 (-)
DBA/2J	ENSMUSG00185042381	protein coding gene	Chr9:107319359-107342492 (-)
FVB/NJ	ENSMUSG00205025849	protein coding gene	Chr9:107252629-107275775 (-)
JF1/MsJ	ENSUMUG00000040934	protein coding gene	Chr9:107088683-107111665 (-)
LP/J	ENSMUSG00230045954	protein coding gene	Chr9:107439303-107462434 (-)
NOD/ShiLtJ	ENSMUSG00190046565	protein coding gene	Chr9:106906989-106930123 (-)
NZO/HlLtJ	ENSMUSG00225023040	protein coding gene	Chr9:107689191-107712335 (-)
PWK/PhJ	ENSLUMG00010028350	protein coding gene	Chr9:107100537-107124409 (-)
SPRET/EiJ	ENSMSPG00010037502	protein coding gene	Chr9:108897056-108920440 (-)
WSB/EiJ	ENSIUOG00005034196	protein coding gene	Chr9:106361475-106384596 (-)

Human Ortholog

PTPN23, protein tyrosine phosphatase non-receptor type 23

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTPN23, protein tyrosine phosphatase non-receptor type 23
Synonyms

HD-PTP, HDPTP, NEDBASS, PTP-TD14
Links

HGNC:14406

NCBI Gene ID: 25930

UniProt: Q9H3S7
Chr Location

3p21.31; chr3:47381011-47413442 (+) GRCh38

MGI Vertebrate Homology

Ptpn23 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PTPN23
Gene Tree

Ptpn23

less

Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

4
Gene trapped

8
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

58 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryos homozygous for a gene trap allele are significantly growth retarded and fail to reach the E8.5 stage.

less

All GO Annotations

61
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

78
cDNA Data

57
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptpn23

ZFIN ptpn23a, ptpn23b

less

All Sequences

48
RefSeq

6
UniProt

2
CCDS

CCDS40780.1

Ensembl

ENSMUSG00000036057 (Evidence)
NCBI Gene

104831

			Length	Strain/Species	Flank
genomic	104831	NCBI Gene Model \| MGI Sequence Detail	23127	C57BL/6J	± kb
transcript	NM_001081043	RefSeq \| MGI Sequence Detail	5384	C57BL/6
polypeptide	Q6PB44	UniProt \| EBI \| MGI Sequence Detail	1692	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000013458 tyrosine-protein phosphatase non-receptor type 23

(term hierarchy)
PDB

2W10
EC

3.1.3.48
InterPro Domains

IPR025304 ALIX V-shaped domain

IPR004328 BRO1 domain

IPR038499 BRO1 domain superfamily

IPR050348 Protein-Tyrosine Phosphatase

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR000242 Tyrosine-specific protein phosphatase, PTPase domain

IPR000387 Tyrosine-specific protein phosphatases domain
GlyGen

Q6PB44 20 sites, 1 O-linked glycan (13 sites)

less

All nucleic 60

cDNA 58

Primer pair 1

Other 1

Antibodies 1

Microarray probesets 3

Summaries

All 46

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 17
Earliest

J:77230 Tanaka K, et al., Spermatogonia-dependent expression of testicular genes in mice. Dev Biol. 2002 Jun 15;246(2):466-79
Latest

J:382309 He Y, et al., PTPN23-dependent activation of PI3KC2alpha is a therapeutic vulnerability of BRAF-mutant cancers. J Exp Med. 2025 Mar 3;222(3)

TSS for Ptpn23:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr91613	Chr9:110237291-110237302 (-)	-19 bp
Tssr91612	Chr9:110237276-110237285 (-)	-3 bp
Tssr91611	Chr9:110237228-110237272 (-)	28 bp
Tssr91610	Chr9:110237199-110237223 (-)	67 bp
Tssr91609	Chr9:110217419-110217431 (-)	19,853 bp
Tssr91608	Chr9:110217295-110217311 (-)	19,975 bp
Tssr91607	Chr9:110217271-110217290 (-)	19,997 bp
Tssr91606	Chr9:110217152-110217170 (-)	20,117 bp
Tssr91605	Chr9:110216776-110216797 (-)	20,491 bp
Tssr91604	Chr9:110216709-110216729 (-)	20,559 bp
Tssr91603	Chr9:110216653-110216664 (-)	20,619 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24