Arhgap44 MGI Mouse Gene Detail - MGI:2144423 - Rho GTPase activating protein 44

Symbol

Arhgap44
Name

Rho GTPase activating protein 44
Synonyms

AU040829

Feature Type

protein coding gene
IDs

MGI:2144423
NCBI Gene: 216831
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:64892865-65053787 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 40.42 cM
Mapping Data

2 experiments

SNPs within 2kb

1539 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2144423	protein coding gene	Chr11:64892865-65053817 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018474	protein coding gene	Chr11:65189266-65359666 (-)
A/J	MGP_AJ_G0018443	protein coding gene	Chr11:62759394-62925136 (-)
AKR/J	MGP_AKRJ_G0018412	protein coding gene	Chr11:64663900-64825343 (-)
BALB/cJ	MGP_BALBcJ_G0018414	protein coding gene	Chr11:63016786-63184157 (-)
C3H/HeJ	MGP_C3HHeJ_G0018227	protein coding gene	Chr11:64635329-64812805 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018866	protein coding gene	Chr11:67171397-67337311 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016510	protein coding gene	Chr11:59776308-59947437 (-)
CAST/EiJ	MGP_CASTEiJ_G0017783	protein coding gene	Chr11:64859169-65023452 (-)
CBA/J	MGP_CBAJ_G0018201	protein coding gene	Chr11:70128255-70309746 (-)
DBA/2J	MGP_DBA2J_G0018310	protein coding gene	Chr11:62305453-62467595 (-)
FVB/NJ	MGP_FVBNJ_G0018300	protein coding gene	Chr11:61960382-62122478 (-)
LP/J	MGP_LPJ_G0018382	protein coding gene	Chr11:65729572-65892192 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018324	protein coding gene	Chr11:71015826-71189025 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018907	protein coding gene	Chr11:64864141-65037331 (-)
PWK/PhJ	MGP_PWKPhJ_G0017557	protein coding gene	Chr11:62932312-63098074 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017347	protein coding gene	Chr11:64705664-64886132 (-)
WSB/EiJ	MGP_WSBEiJ_G0017836	protein coding gene	Chr11:64477650-64641356 (-)

Human Ortholog

ARHGAP44, Rho GTPase activating protein 44

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGAP44, Rho GTPase activating protein 44
Synonyms

NPC-A-10, RICH2
Links

HGNC:29096

NCBI Gene ID: 9912

neXtProt AC: NX_Q17R89

UniProt: Q17R89
Chr Location

17p12; chr17:12789512-12991644 (+) GRCh38.p7

Alliance of Genome Resources

Arhgap44 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ARHGAP44
Gene Tree

Arhgap44

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

5
Genomic Mutations

1 involving Arhgap44
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased brain weight, abnormal dendritic spine morphology, hypoactivity, increased self-grooming behavior, abnormal response to novel objects, and impaired motor learning.

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All GO Annotations

41
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

836
Tissues

40
cDNA Data

9
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arhgap44

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Arhgap44 interacts with 249 markers (Mir7-2, Mir7b, Mir9-1, ...) View All

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All Sequences

62
RefSeq

16
UniProt

3
CCDS

CCDS36180.1

Ensembl

ENSMUSG00000033389 (Evidence)
NCBI Gene

216831

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033389	Ensembl Gene Model \| MGI Sequence Detail	160923	C57BL/6J	± kb
transcript	ENSMUST00000093002	Ensembl \| MGI Sequence Detail	3982	Not Applicable
polypeptide	ENSMUSP00000090681	Ensembl \| MGI Sequence Detail	814	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013997 Rho GTPase-activating protein 44

(term hierarchy)
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR004148 BAR domain

IPR000198 Rho GTPase-activating protein domain

IPR008936 Rho GTPase activation protein

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All nucleic 9

cDNA 9

Microarray probesets 4

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MGI:2144278, MGI:2144545

Summaries

All 38

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 10
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:250218 Sarowar T, et al., Object Phobia and Altered RhoA Signaling in Amygdala of Mice Lacking RICH2. Front Mol Neurosci. 2017;10:180

TSS for Arhgap44:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108463	Chr11:65053733-65053802 (-)	19 bp
Tssr108462	Chr11:64923258-64923273 (-)	130,521 bp
Tssr108461	Chr11:64923228-64923239 (-)	130,553 bp
Tssr108460	Chr11:64922549-64922556 (-)	131,234 bp
Tssr3518	Chr11:64900769-64900800 (-)	153,002 bp
Tssr108459	Chr11:64893904-64893908 (-)	159,881 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 05/09/2023 MGI 6.22