Mief2 MGI Mouse Gene Detail - MGI:2144199 - mitochondrial elongation factor 2

Symbol

Mief2
Name

mitochondrial elongation factor 2
Synonyms

LOC237781, Smcr7

Feature Type

protein coding gene
IDs

MGI:2144199
NCBI Gene: 237781
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:60619224-60623777 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.81 cM
Mapping Data

4 experiments

SNPs within 2kb

150 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2144199	protein coding gene	Chr11:60619224-60623777 (+)
129S1/SvImJ	ENSMUSG00200036267	protein coding gene	Chr11:57542168-57546721 (+)
A/J	ENSMUSG00195037261	protein coding gene	Chr11:57572738-57577299 (+)
AKR/J	ENSMUSG00220049878	protein coding gene	Chr11:57689622-57694175 (+)
BALB/cJ	ENSMUSG00180048888	protein coding gene	Chr11:57631854-57636407 (+)
C3H/HeJ	ENSMUSG00175036403	protein coding gene	Chr11:57590067-57594628 (+)
C57BL/6NJ	ENSMUSG00215028321	protein coding gene	Chr11:57338615-57343168 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016461	protein coding gene	Chr11:55554663-55559787 (+)
CAST/EiJ	ENSTCUG00005038442	protein coding gene	Chr11:57121322-57125883 (+)
CBA/J	ENSMUSG00210036706	protein coding gene	Chr11:57423095-57427656 (+)
DBA/2J	ENSMUSG00185041371	protein coding gene	Chr11:57618237-57622790 (+)
FVB/NJ	ENSMUSG00205040513	protein coding gene	Chr11:57500504-57505039 (+)
JF1/MsJ	ENSUMUG00000047407	protein coding gene	Chr11:58023040-58027601 (+)
LP/J	ENSMUSG00230043749	protein coding gene	Chr11:58763489-58768042 (+)
NOD/ShiLtJ	ENSMUSG00190040794	protein coding gene	Chr11:57616245-57620798 (+)
NZO/HlLtJ	ENSMUSG00225044337	protein coding gene	Chr11:60908701-60913262 (+)
PWK/PhJ	ENSLUMG00010026395	protein coding gene	Chr11:57543322-57547865 (+)
SPRET/EiJ	ENSMSPG00010035951	protein coding gene	Chr11:58220051-58224619 (+)
WSB/EiJ	ENSIUOG00005033129	protein coding gene	Chr11:57531577-57536132 (+)

Human Ortholog

MIEF2, mitochondrial elongation factor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIEF2, mitochondrial elongation factor 2
Synonyms

COXPD49, D3B, MID49, SMCR7
Links

HGNC:17920

NCBI Gene ID: 125170

UniProt: Q96C03
Chr Location

17p11.2; chr17:18259527-18266552 (+) GRCh38

MGI Vertebrate Homology

Mief2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MIEF2
Gene Tree

Mief2

Diseases

1 with human MIEF2 associations

				Human Disease	Mouse Models
				combined oxidative phosphorylation deficiency 49 IDs combined oxidative phosphorylation deficiency 49 DOID:0112110 OMIM:619024

Click on a disease name to see all genes associated with that disease.

References

2 with disease annotations

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Phenotype Summary

20 phenotype references

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Targeted

5
Genomic Mutations

3 involving Mief2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

12 strains or lines available

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All GO Annotations

26
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

7
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mief2

ZFIN mief2

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All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS24796.1

Ensembl

ENSMUSG00000018599 (Evidence)
NCBI Gene

237781

			Length	Strain/Species	Flank
genomic	237781	NCBI Gene Model \| MGI Sequence Detail	4554	C57BL/6J	± kb
transcript	NM_001009927	RefSeq \| MGI Sequence Detail	2564	C57BL/6
polypeptide	Q5NCS9	UniProt \| EBI \| MGI Sequence Detail	454	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015278 Smith-Magenis syndrome chromosome region candidate gene 7 protein

(term hierarchy)
PDB

4WOY
InterPro Domains

IPR024810 MAB21L/Cyclic GMP-AMP synthase-like receptor

IPR046906 Mab-21-like, HhH/H2TH-like domain

IPR045909 Mitochondrial dynamics protein MID49/MID51

IPR049097 Mitochondrial dynamics protein MID51-like, C-terminal domain
GlyGen

Q5NCS9 1 site

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All nucleic 7

cDNA 7

Microarray probesets 2

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MGI:2684857

Summaries

All 52

Developmental Gene Expression 1

Diseases 2

Gene Ontology 9

Phenotypes 20
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:365237 Aoto M, et al., The splicing factor Acin1 is essential for embryonic development but has limited effects on muscle structure and homeostasis. Sci Rep. 2025;15(1):14017

TSS for Mief2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101913	Chr11:60619239-60619280 (+)	36 bp
Tssr101914	Chr11:60619307-60619328 (+)	94 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24