Wsb2 MGI Mouse Gene Detail - MGI:2144041 - WD repeat and SOCS box-containing 2

Symbol

Wsb2
Name

WD repeat and SOCS box-containing 2

Feature Type

protein coding gene
IDs

MGI:2144041
NCBI Gene: 59043
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:117495370-117516666 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 56.88 cM
Mapping Data

1 experiment

SNPs within 2kb

173 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2144041	protein coding gene	Chr5:117495369-117516666 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029987	protein coding gene	Chr5:120441831-120466721 (+)
A/J	MGP_AJ_G0029951	protein coding gene	Chr5:115540379-115561913 (+)
AKR/J	MGP_AKRJ_G0029890	protein coding gene	Chr5:119275286-119297905 (+)
BALB/cJ	MGP_BALBcJ_G0029962	protein coding gene	Chr5:116958948-116979532 (+)
C3H/HeJ	MGP_C3HHeJ_G0029682	protein coding gene	Chr5:119793929-119816391 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030417	protein coding gene	Chr5:125022549-125045714 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027643	protein coding gene	Chr5:110301898-110322349 (+)
CAST/EiJ	MGP_CASTEiJ_G0029091	protein coding gene	Chr5:118798473-118819750 (+)
CBA/J	MGP_CBAJ_G0029650	protein coding gene	Chr5:129848091-129871159 (+)
DBA/2J	MGP_DBA2J_G0029800	protein coding gene	Chr5:115639047-115660133 (+)
FVB/NJ	MGP_FVBNJ_G0029756	protein coding gene	Chr5:114503846-114524064 (+)
LP/J	MGP_LPJ_G0029888	protein coding gene	Chr5:120939985-120963210 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029787	protein coding gene	Chr5:134066281-134090991 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030458	protein coding gene	Chr5:118799364-118823091 (+)
PWK/PhJ	MGP_PWKPhJ_G0028804	protein coding gene	Chr5:114331758-114354731 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028642	protein coding gene	Chr5:116364333-116388263 (+)
WSB/EiJ	MGP_WSBEiJ_G0029166	protein coding gene	Chr5:119371432-119394294 (+)

Human Ortholog

WSB2, WD repeat and SOCS box containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WSB2, WD repeat and SOCS box containing 2
Synonyms

SBA2
Links

HGNC:19222

NCBI Gene ID: 55884

neXtProt AC: NX_Q9NYS7

UniProt: Q9NYS7
Chr Location

12q24.23; chr12:118032687-118062430 (-) GRCh38

Alliance of Genome Resources

Wsb2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WSB2
Gene Tree

Wsb2

less

Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

57
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

51
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Wsb2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development	DNA-templated transcription

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

856
Tissues

48
cDNA Data

10
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wsb2

less

Wsb2 interacts with 154 markers (Mir1b, Mir9-1, Mir9-2, ...) View All

less

All Sequences

56
RefSeq

4
UniProt

3
CCDS

CCDS19604.1

Ensembl

ENSMUSG00000029364 (Evidence)
NCBI Gene

59043

			Length	Strain/Species	Flank
genomic	59043	NCBI Gene Model \| MGI Sequence Detail	21297	C57BL/6J	± kb
transcript	NM_021539	RefSeq \| MGI Sequence Detail	2408	C57BL/6
polypeptide	O54929	UniProt \| EBI \| MGI Sequence Detail	404	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000017458 WD repeat and SOCS box-containing protein 2

(term hierarchy)
InterPro Domains

IPR020472 G-protein beta WD-40 repeat

IPR001496 SOCS box domain

IPR036036 SOCS box-like domain superfamily

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

less

All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 6

Summaries

All 43

Developmental Gene Expression 4

Gene Ontology 2

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Wsb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48381	Chr5:117494695-117494706 (+)	-669 bp
Tssr48382	Chr5:117494908-117494941 (+)	-445 bp
Tssr48383	Chr5:117495275-117495288 (+)	-88 bp
Tssr48384	Chr5:117495339-117495420 (+)	10 bp
Tssr48385	Chr5:117501563-117501577 (+)	6,200 bp
Tssr48386	Chr5:117501578-117501617 (+)	6,228 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/21/2023 MGI 6.22