Zfr2 MGI Mouse Gene Detail - MGI:2143792 - zinc finger RNA binding protein 2

Symbol

Zfr2
Name

zinc finger RNA binding protein 2
Synonyms

2010013I23Rik, 9130206N08Rik

Feature Type

protein coding gene
IDs

MGI:2143792
NCBI Gene: 103406
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr10:81068989-81087957 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

2 experiments

SNPs within 2kb

453 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2143792	protein coding gene	Chr10:81068967-81087957 (+)
129S1/SvImJ	ENSMUSG00200043832	protein coding gene	Chr10:77696136-77715098 (+)
A/J	ENSMUSG00195049018	protein coding gene	Chr10:78091409-78110369 (+)
AKR/J	ENSMUSG00220046705	protein coding gene	Chr10:77689096-77708056 (+)
BALB/cJ	ENSMUSG00180052158	protein coding gene	Chr10:78101861-78120821 (+)
C3H/HeJ	ENSMUSG00175048873	protein coding gene	Chr10:77972612-77991574 (+)
C57BL/6NJ	ENSMUSG00215052278	protein coding gene	Chr10:77714464-77733434 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015627	protein coding gene	Chr10:75233735-75253267 (+)
CAST/EiJ	ENSTCUG00005051022	protein coding gene	Chr10:77596074-77614971 (+)
CBA/J	ENSMUSG00210049003	protein coding gene	Chr10:77828640-77847598 (+)
DBA/2J	ENSMUSG00185046289	protein coding gene	Chr10:78171070-78190034 (+)
FVB/NJ	ENSMUSG00205027787	protein coding gene	Chr10:77883884-77902846 (+)
JF1/MsJ	ENSUMUG00000019157	protein coding gene	Chr10:79398499-79417450 (+)
LP/J	ENSMUSG00230050600	protein coding gene	Chr10:79940654-79959618 (+)
NOD/ShiLtJ	ENSMUSG00190042962	protein coding gene	Chr10:78084771-78103731 (+)
NZO/HlLtJ	ENSMUSG00225052495	protein coding gene	Chr10:84227223-84246187 (+)
PWK/PhJ	ENSLUMG00010044458	protein coding gene	Chr10:77762168-77781134 (+)
SPRET/EiJ	ENSMSPG00010031224	protein coding gene	Chr10:79372024-79391198 (+)
WSB/EiJ	ENSIUOG00005050036	protein coding gene	Chr10:77824835-77843796 (+)

Human Ortholog

ZFR2, zinc finger RNA binding protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZFR2, zinc finger RNA binding protein 2
Synonyms

KIAA1086
Links

HGNC:29189

NCBI Gene ID: 23217

UniProt: Q9UPR6
Chr Location

19p13.3; chr19:3804024-3869038 (-) GRCh38

MGI Vertebrate Homology

Zfr2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZFR2
Gene Tree

Zfr2

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

2
Genomic Mutations

1 involving Zfr2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

35 strains or lines available

Mice homozygous for a null allele exhibit normal fertility.

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All GO Annotations

5
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

598
Tissues

1
cDNA Data

7
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

50
RefSeq

3
UniProt

4
CCDS

CCDS48642.1

Ensembl

ENSMUSG00000034949 (Evidence)
NCBI Gene

103406

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034949	Ensembl Gene Model \| MGI Sequence Detail	18969	C57BL/6J	± kb
transcript	ENSMUST00000117798	Ensembl \| MGI Sequence Detail	3349	Not Applicable
polypeptide	ENSMUSP00000113913	Ensembl \| MGI Sequence Detail	874	Not Applicable

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UniProt

4 Sequences
InterPro Domains

IPR006561 DZF domain

IPR049402 DZF domain, C-terminal

IPR049401 DZF domain, N-terminal

IPR003604 Matrin/U1-C-like, C2H2-type zinc finger

IPR043519 Nucleotidyltransferase superfamily

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

E9Q5M4 1 site

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All nucleic 8

cDNA 8

Microarray probesets 3

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MGI:1919328

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 11
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:326370 Cauchi LM, et al., Zinc finger RNA binding protein 2 (ZFR2) is not required for male fertility in the mouse. Dev Biol. 2022 Jun 6;489:55-61

TSS for Zfr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94720	Chr10:81068981-81069025 (+)	14 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24