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Ano10 Gene Detail
Summary
  • Symbol
    Ano10
  • Name
    anoctamin 10
  • Synonyms
    Tmem16k
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143103
    NCBI Gene: 102566
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:122004940-122123489 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 72.94 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    506 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143103
 protein coding gene Chr9:122004940-122123508 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035459
 protein coding gene Chr9:125154273-125281572 (-)
A/J MGP_AJ_G0035440
 protein coding gene Chr9:120387715-120505500 (-)
AKR/J MGP_AKRJ_G0035373
 protein coding gene Chr9:123606004-123731315 (-)
BALB/cJ MGP_BALBcJ_G0035436
 protein coding gene Chr9:120296618-120425251 (-)
C3H/HeJ MGP_C3HHeJ_G0035143
 protein coding gene Chr9:124056522-124178525 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035959
 protein coding gene Chr9:128581306-128704495 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032841
 protein coding gene Chr9:117543087-117661787 (-)
CAST/EiJ MGP_CASTEiJ_G0034448
 protein coding gene Chr9:124099412-124215510 (-)
CBA/J MGP_CBAJ_G0035111
 protein coding gene Chr9:133303305-133431075 (-)
DBA/2J MGP_DBA2J_G0035270
 protein coding gene Chr9:119835040-119952512 (-)
FVB/NJ MGP_FVBNJ_G0035217
 protein coding gene Chr9:118746229-118872803 (-)
LP/J MGP_LPJ_G0035349
 protein coding gene Chr9:125494093-125619605 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035258
 protein coding gene Chr9:134178063-134300722 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035978
 protein coding gene Chr9:124042399-124159565 (-)
PWK/PhJ MGP_PWKPhJ_G0034152
 protein coding gene Chr9:120294532-120413248 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033989
 protein coding gene Chr9:124168555-124286962 (-)
WSB/EiJ MGP_WSBEiJ_G0034568
 protein coding gene Chr9:123894854-124022987 (-)



Homology
more
  • Human Ortholog
    ANO10, anoctamin 10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANO10, anoctamin 10
  • Synonyms
    SCAR10, TMEM16K
  • Links
    NCBI Gene ID: 55129
    neXtProt AC: NX_Q9NW15
    UniProt: Q9NW15

  • Chr Location
    3p22.1-p21.33; chr3:43366324-43691594 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human ANO10 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele fail to exhibit calcium-activated chloride ion secretion in the jejunum.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    67
  • cDNA Data
    43
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037949 Ensembl Gene Model | MGI Sequence Detail 118550 C57BL/6J ±  kb
    transcript ENSMUST00000042546 Ensembl | MGI Sequence Detail 2653 Not Applicable  
    polypeptide ENSMUSP00000045214 Ensembl | MGI Sequence Detail 659 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 43

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:294632 Petkovic M, et al., TMEM16K is an interorganelle regulator of endosomal sorting. Nat Commun. 2020 Jul 3;11(1):3298
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/14/2023
    MGI 6.22     		The Jackson Laboratory