Mtmr10 Gene Detail

Summary

• Symbol
  Mtmr10
• Name
  myotubularin related protein 10

• Feature Type
  protein coding gene
• IDs
  MGI:2142292
  NCBI Gene: 233315
• Alliance
  gene page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr7:63937418-63990554 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 34.63 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  538 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2142292	protein coding gene	Chr7:63937401-63990554 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032335	protein coding gene	Chr7:65423689-65478805 (+)
A/J	MGP_AJ_G0032314	protein coding gene	Chr7:64157703-64211356 (+)
AKR/J	MGP_AKRJ_G0032250	protein coding gene	Chr7:65512793-65567271 (+)
BALB/cJ	MGP_BALBcJ_G0032326	protein coding gene	Chr7:63898003-63950904 (+)
C3H/HeJ	MGP_C3HHeJ_G0032039	protein coding gene	Chr7:66159991-66217421 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032819	protein coding gene	Chr7:68228167-68301855 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029826	protein coding gene	Chr7:67103467-67156908 (+)
CAST/EiJ	MGP_CASTEiJ_G0031368	protein coding gene	Chr7:56856851-56911373 (+)
CBA/J	MGP_CBAJ_G0032005	protein coding gene	Chr7:70452682-70505755 (+)
DBA/2J	MGP_DBA2J_G0032161	protein coding gene	Chr7:62909567-62962936 (+)
FVB/NJ	MGP_FVBNJ_G0032115	protein coding gene	Chr7:63009038-63061954 (+)
LP/J	MGP_LPJ_G0032241	protein coding gene	Chr7:66656527-66716272 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032152	protein coding gene	Chr7:70726739-70780807 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032836	protein coding gene	Chr7:64794960-64850285 (+)
PWK/PhJ	MGP_PWKPhJ_G0031088	protein coding gene	Chr7:55918712-55972192 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030929	protein coding gene	Chr7:51932436-51986889 (+)
WSB/EiJ	MGP_WSBEiJ_G0031486	protein coding gene	Chr7:65178696-65233933 (+)

Homology

• Human Ortholog
  MTMR10, myotubularin related protein 10

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  MTMR10, myotubularin related protein 10
  
• Links
  HGNC:25999

  NCBI Gene ID: 54893

  neXtProt AC: NX_Q9NXD2

  UniProt: Q9NXD2

  
  
• Chr Location
  15q13.3; chr15:30918716-30991628 (-)  GRCh38

---

• Alliance of Genome Resources
  Mtmr10 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: MTMR10
• Gene Tree
  Mtmr10
  

Human Diseases

• References
  2 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  1 phenotype from multigenic genotypes
  22 phenotype references
  

• All Mutations and Alleles
  14
• Chemically induced (other)
  1
• Endonuclease-mediated
  3
• Gene trapped
  2
• Radiation induced
  1
• Targeted
  7
• Genomic Mutations
  6 involving Mtmr10
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  29 strains or lines available

Mice homozygous for a null allele exhibit normal preweaning survival.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  2
• GO References
  2

Expression

• Assay Results
  795
• Tissues
  11
• cDNA Data
  83
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase mtmr10

Interactions

• Mtmr10 interacts with 310 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

Sequences &
Gene Models

• All Sequences
  59
• RefSeq
  6
• UniProt
  5
• CCDS
  CCDS39976.1

• Ensembl
  ENSMUSG00000030522 (Evidence)
• NCBI Gene
  233315

Representative Sequences			Length	Strain/Species
genomic	233315	NCBI Gene Model | MGI Sequence Detail	53137	C57BL/6J
transcript	NM_172742	RefSeq | MGI Sequence Detail	5182	C57BL/6
polypeptide	Q7TPM9	UniProt | EBI | MGI Sequence Detail	771	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000010732 myotubularin-related protein 10
  (term hierarchy)
• InterPro Domains
  IPR036004 MTMR10, PH-GRAM domain
  IPR030564 Myotubularin family
  IPR010569 Myotubularin-like, phosphatase domain
  IPR022587 Myotubularin-related 12-like C-terminal domain
  IPR030573 Myotubularin-related protein 10, protein tyrosine phosphatase domain
  IPR011993 PH-like domain superfamily
  IPR029021 Protein-tyrosine phosphatase-like

Molecular
Reagents

• All nucleic 83

  cDNA 83

  
  

  Microarray probesets 5

Other
Accession IDs

MGI:2142333

References

• Summaries
  All 46

  Developmental Gene Expression 1

  Diseases 2

  Gene Ontology 2

  Phenotypes 22
• Earliest
  J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
• Latest
  J:322231 Malwade S, et al., Identification of Vulnerable Interneuron Subtypes in 15q13.3 Microdeletion Syndrome Using Single-Cell Transcriptomics. Biol Psychiatry. 2022 Apr 15;91(8):727-739

TSS for Mtmr10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr67007	Chr7:63937217-63937251 (+)	-184 bp
Tssr67008	Chr7:63937401-63937410 (+)	-12 bp
Tssr67009	Chr7:63937413-63937424 (+)	1 bp
Tssr67010	Chr7:63937425-63937463 (+)	26 bp
Tssr67011	Chr7:63937476-63937497 (+)	69 bp