Pwwp2b MGI Mouse Gene Detail - MGI:2142008

Symbol

Pwwp2b
Name

PWWP domain containing 2B
Synonyms

D7Ertd517e, D930023J19Rik, Pwwp2

Feature Type

protein coding gene
IDs

MGI:2142008
NCBI Gene: 101631
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:138828398-138847172 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 84.39 cM
Mapping Data

3 experiments

SNPs within 2kb

591 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2142008	protein coding gene	Chr7:138828398-138849819 (+)
129S1/SvImJ	ENSMUSG00200044537	protein coding gene	Chr7:125384033-125403530 (+)
A/J	ENSMUSG00195033150	protein coding gene	Chr7:129860754-129880251 (+)
AKR/J	ENSMUSG00220028981	protein coding gene	Chr7:123349030-123368606 (+)
BALB/cJ	ENSMUSG00180037192	protein coding gene	Chr7:126558589-126578088 (+)
C3H/HeJ	ENSMUSG00175038619	protein coding gene	Chr7:127286876-127306376 (+)
C57BL/6NJ	ENSMUSG00215044899	protein coding gene	Chr7:126561309-126580808 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030616	protein coding gene	Chr7:141324443-141343316 (+)
CAST/EiJ	ENSTCUG00005050279	protein coding gene	Chr7:129843567-129863071 (+)
CBA/J	ENSMUSG00210026233	protein coding gene	Chr7:127025877-127045391 (+)
DBA/2J	ENSMUSG00185014333	protein coding gene	Chr7:131323235-131342731 (+)
FVB/NJ	ENSMUSG00205032505	protein coding gene	Chr7:127010124-127029623 (+)
JF1/MsJ	ENSUMUG00000045374	protein coding gene	Chr7:136403062-136422626 (+)
LP/J	ENSMUSG00230037368	protein coding gene	Chr7:137487062-137506558 (+)
NOD/ShiLtJ	ENSMUSG00190024964	protein coding gene	Chr7:127152423-127171919 (+)
NZO/HlLtJ	ENSMUSG00225050988	protein coding gene	Chr7:135704251-135723746 (+)
PWK/PhJ	ENSLUMG00010042606	protein coding gene	Chr7:125558286-125577839 (+)
SPRET/EiJ	ENSMSPG00010031377	protein coding gene	Chr7:126911556-126930767 (+)
WSB/EiJ	ENSIUOG00005028417	protein coding gene	Chr7:127846779-127866273 (+)

Human Ortholog

PWWP2B, PWWP domain containing 2B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PWWP2B, PWWP domain containing 2B
Synonyms

bA432J24.1, pp8607, PWWP2
Links

HGNC:25150

NCBI Gene ID: 170394

UniProt: Q6NUJ5
Chr Location

10q26.3; chr10:132397168-132417859 (+) GRCh38

MGI Vertebrate Homology

Pwwp2b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PWWP2B
Gene Tree

Pwwp2b

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in adipose tissue exhibit increased adaptive thermogenesis and protection from high-fat diet induced obesity and metabolic dysregulation.

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All GO Annotations

23
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

29

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pwwp2b

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All Sequences

53
RefSeq

6
UniProt

4
CCDS

CCDS40169.1, CCDS52427.1

Ensembl

ENSMUSG00000060260 (Evidence)
NCBI Gene

101631

			Length	Strain/Species	Flank
genomic	101631	NCBI Gene Model \| MGI Sequence Detail	18775	C57BL/6J	± kb
transcript	NM_001098636	RefSeq \| MGI Sequence Detail	2640	ZRU/MplStud
polypeptide	E9Q9M8	UniProt \| EBI \| MGI Sequence Detail	600	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000029703 PWWP domain-containing protein 2B

(term hierarchy)
InterPro Domains

IPR050390 DNA Cytosine-5 Methyltransferase

IPR000313 PWWP domain

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All nucleic 30

cDNA 29

Primer pair 1

Microarray probesets 3

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MGI:1261860

Summaries

All 40

Gene Ontology 8

Phenotypes 8
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pwwp2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69710	Chr7:138828127-138828145 (+)	-262 bp
Tssr69711	Chr7:138828326-138828372 (+)	-49 bp
Tssr69712	Chr7:138828393-138828448 (+)	23 bp
Tssr69713	Chr7:138834843-138834885 (+)	6,466 bp
Tssr69714	Chr7:138844676-138844681 (+)	16,281 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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