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Tsen2 Gene Detail
Summary
  • Symbol
    Tsen2
  • Name
    tRNA splicing endonuclease subunit 2
  • Synonyms
    MGC:69703
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141599
    NCBI Gene: 381802
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:115521652-115555297 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 53.58 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1387 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141599
 protein coding gene Chr6:115521625-115555589 (+)
129S1/SvImJ ENSMUSG00200045730
 protein coding gene Chr6:112743603-112777764 (+)
A/J ENSMUSG00195042519
 protein coding gene Chr6:112127854-112161825 (+)
AKR/J ENSMUSG00220033567
 protein coding gene Chr6:111047840-111088323 (+)
BALB/cJ ENSMUSG00180037920
 protein coding gene Chr6:112493532-112527496 (+)
C3H/HeJ ENSMUSG00175028697
 protein coding gene Chr6:64892650-64933129 (-)
C57BL/6NJ ENSMUSG00215022601
 protein coding gene Chr6:112480604-112514572 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028752
 protein coding gene Chr6:110644797-110684767 (+)
CAST/EiJ ENSTCUG00005026588
 protein coding gene Chr6:112348560-112382528 (+)
CBA/J ENSMUSG00210038863
 protein coding gene Chr6:112304745-112345228 (+)
DBA/2J ENSMUSG00185042517
 protein coding gene Chr6:112942128-112976290 (+)
FVB/NJ ENSMUSG00205021829
 protein coding gene Chr6:111372544-111413373 (+)
JF1/MsJ ENSUMUG00000022523
 protein coding gene Chr6:111592895-111633390 (+)
LP/J ENSMUSG00230046713
 protein coding gene Chr6:114146457-114180618 (+)
NOD/ShiLtJ ENSMUSG00190035850
 protein coding gene Chr6:111896315-111930477 (+)
NZO/HlLtJ ENSMUSG00225045218
 protein coding gene Chr6:116002124-116036289 (+)
PWK/PhJ ENSLUMG00010025400
 protein coding gene Chr6:110898814-110932757 (+)
SPRET/EiJ ENSMSPG00010043150
 protein coding gene Chr6:113690529-113725118 (+)
WSB/EiJ ENSIUOG00005024834
 protein coding gene Chr6:112638036-112672363 (+)



Homology
more
  • Human Ortholog
    TSEN2, tRNA splicing endonuclease subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSEN2, tRNA splicing endonuclease subunit 2
  • Synonyms
    PCH2B, SEN2, SEN2L
  • Links
    NCBI Gene ID: 80746
    UniProt: Q8NCE0

  • Chr Location
    3p25.2; chr3:12480231-12541549 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TSEN2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    26
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 381802 NCBI Gene Model | MGI Sequence Detail 33646 C57BL/6J ±  kb
transcript NM_001411785 RefSeq | MGI Sequence Detail 3523 C57BL/6  
polypeptide Q6P7W5 UniProt | EBI | MGI Sequence Detail 460 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    Genomic 1
    cDNA 27

    Microarray probesets 4
References
more
  • Summaries
    All 37
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory