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Lrrc8b Gene Detail
Summary
  • Symbol
    Lrrc8b
  • Name
    leucine rich repeat containing 8 family, member B
  • Synonyms
    2210408K08Rik, R75581
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141353
    NCBI Gene: 433926
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:105563641-105637940 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 50.68 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    416 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141353
 protein coding gene Chr5:105563072-105637945 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029825
 protein coding gene Chr5:107305947-107378884 (+)
A/J MGP_AJ_G0029789
 protein coding gene Chr5:103223922-103290278 (+)
AKR/J MGP_AKRJ_G0029734
 protein coding gene Chr5:106580220-106648498 (+)
BALB/cJ MGP_BALBcJ_G0029801
 protein coding gene Chr5:104367613-104435417 (+)
C3H/HeJ MGP_C3HHeJ_G0029523
 protein coding gene Chr5:106997649-107064088 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030255
 protein coding gene Chr5:111788434-111860500 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027490
 protein coding gene Chr5:98324081-98389698 (+)
CAST/EiJ MGP_CASTEiJ_G0028937
 protein coding gene Chr5:105892010-105960363 (+)
CBA/J MGP_CBAJ_G0029491
 protein coding gene Chr5:115497267-115573196 (+)
DBA/2J MGP_DBA2J_G0029637
 protein coding gene Chr5:103384487-103456740 (+)
FVB/NJ MGP_FVBNJ_G0029594
 protein coding gene Chr5:102104177-102169174 (+)
LP/J MGP_LPJ_G0029725
 protein coding gene Chr5:107920824-107995205 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029626
 protein coding gene Chr5:120565102-120637833 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030289
 protein coding gene Chr5:106108287-106181584 (+)
PWK/PhJ MGP_PWKPhJ_G0028650
 protein coding gene Chr5:101849430-101923323 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028488
 protein coding gene Chr5:103589735-103662055 (+)
WSB/EiJ MGP_WSBEiJ_G0029010
 protein coding gene Chr5:106427887-106497818 (+)



Homology
more
  • Human Ortholog
    LRRC8B, leucine rich repeat containing 8 VRAC subunit B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRC8B, leucine rich repeat containing 8 VRAC subunit B
  • Synonyms
    TALRRP, TA-LRRP
  • Links
    NCBI Gene ID: 23507
    neXtProt AC: NX_Q6P9F7
    UniProt: Q6P9F7

  • Chr Location
    1p22.2; chr1:89524829-89597861 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Mice homozygous for a null allele exhibit normal response to viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070639 Ensembl Gene Model | MGI Sequence Detail 74300 C57BL/6J ±  kb
transcript ENSMUST00000112707 Ensembl | MGI Sequence Detail 6726 Not Applicable  
polypeptide ENSMUSP00000108327 Ensembl | MGI Sequence Detail 803 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 3
Other
Accession IDs
less
MGI:1917430
References
more
  • Summaries
    All 34
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:333948 Lopez-Cayuqueo KI, et al., Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy. J Am Soc Nephrol. 2022 Aug;33(8):1528-1545
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory