Lrrc8b MGI Mouse Gene Detail - MGI:2141353 - leucine rich repeat containing 8 family, member B

Symbol

Lrrc8b
Name

leucine rich repeat containing 8 family, member B
Synonyms

2210408K08Rik, R75581

Feature Type

protein coding gene
IDs

MGI:2141353
NCBI Gene: 433926
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr5:105563641-105637940 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 50.68 cM
Mapping Data

2 experiments

SNPs within 2kb

1651 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2141353	protein coding gene	Chr5:105563072-105637945 (+)
129S1/SvImJ	ENSMUSG00200005292	protein coding gene	Chr5:99295769-99370066 (+)
A/J	ENSMUSG00195032110	protein coding gene	Chr5:98755938-98825219 (+)
AKR/J	ENSMUSG00220035729	protein coding gene	Chr5:98314237-98388537 (+)
BALB/cJ	ENSMUSG00180029372	protein coding gene	Chr5:98908079-98977361 (+)
C3H/HeJ	ENSMUSG00175029330	protein coding gene	Chr5:100943882-101012578 (+)
C57BL/6NJ	ENSMUSG00215015538	protein coding gene	Chr5:98965296-99039605 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027490	protein coding gene	Chr5:98324081-98389698 (+)
CAST/EiJ	ENSTCUG00005023448	protein coding gene	Chr5:98193679-98261303 (+)
CBA/J	ENSMUSG00210032060	protein coding gene	Chr5:99701674-99770358 (+)
DBA/2J	ENSMUSG00185041158	protein coding gene	Chr5:102632194-102701281 (+)
FVB/NJ	ENSMUSG00205030770	protein coding gene	Chr5:98611131-98679829 (+)
JF1/MsJ	ENSUMUG00000007078	protein coding gene	Chr5:105640720-105715224 (+)
LP/J	ENSMUSG00230027276	protein coding gene	Chr5:106837078-106911373 (+)
NOD/ShiLtJ	ENSMUSG00190023534	protein coding gene	Chr5:98630111-98704408 (+)
NZO/HlLtJ	ENSMUSG00225024535	protein coding gene	Chr5:114458770-114533067 (+)
PWK/PhJ	ENSLUMG00010013603	protein coding gene	Chr5:97657359-97731680 (+)
SPRET/EiJ	ENSMSPG00010043957	protein coding gene	Chr5:100780418-100798675 (+)
WSB/EiJ	ENSIUOG00005028056	protein coding gene	Chr5:101348396-101417311 (+)

Human Ortholog

LRRC8B, leucine rich repeat containing 8 VRAC subunit B

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRRC8B, leucine rich repeat containing 8 VRAC subunit B
Synonyms

TA-LRRP, TALRRP
Links

HGNC:30692

NCBI Gene ID: 23507

UniProt: Q6P9F7
Chr Location

1p22.2; chr1:89524829-89597861 (+) GRCh38

MGI Vertebrate Homology

Lrrc8b stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LRRC8B
Gene Tree

Lrrc8b

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

1
Spontaneous

1
Targeted

1
Genomic Mutations

3 involving Lrrc8b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available

Mice homozygous for a null allele exhibit normal response to viral infection.

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All GO Annotations

24
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

9

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lrrc8b

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All Sequences

48
RefSeq

10
UniProt

3
CCDS

CCDS39193.1

Ensembl

ENSMUSG00000070639 (Evidence)
NCBI Gene

433926

			Length	Strain/Species	Flank
genomic	ENSMUSG00000070639	Ensembl Gene Model \| MGI Sequence Detail	74300	C57BL/6J	± kb
transcript	ENSMUST00000112707	Ensembl \| MGI Sequence Detail	6726	Not Applicable
polypeptide	ENSMUSP00000108327	Ensembl \| MGI Sequence Detail	803	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030527 volume-regulated anion channel subunit LRRC8B

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR021040 LRRC8, pannexin-like TM region

IPR050333 Small Leucine-Rich Proteoglycans
GlyGen

Q5DU41 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 9

cDNA 9

Microarray probesets 3

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MGI:1917430

Summaries

All 37

Gene Ontology 5

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:333948 Lopez-Cayuqueo KI, et al., Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy. J Am Soc Nephrol. 2022 Aug;33(8):1528-1545

TSS for Lrrc8b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47677	Chr5:105563556-105563596 (+)	-65 bp
Tssr47678	Chr5:105563604-105563715 (+)	19 bp
Tssr47679	Chr5:105594737-105594762 (+)	31,109 bp
Tssr47680	Chr5:105629445-105629458 (+)	65,811 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24