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Upk3b Gene Detail
Summary
  • Symbol
    Upk3b
  • Name
    uroplakin 3B
  • Synonyms
    P35, PMS2L14, UpIIIb
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140882
    NCBI Gene: 100647
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:136067350-136073847 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 75.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140882
protein coding gene Chr5:136067350-136075341 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030197
protein coding gene Chr5:140648430-140656369 (+)
A/J MGP_AJ_G0030165
protein coding gene Chr5:134599847-134607805 (+)
AKR/J MGP_AKRJ_G0030098
protein coding gene Chr5:138954401-138962332 (+)
BALB/cJ MGP_BALBcJ_G0030175
protein coding gene Chr5:135957199-135965421 (+)
C3H/HeJ MGP_C3HHeJ_G0029891
protein coding gene Chr5:139561634-139570485 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030628
protein coding gene Chr5:145880815-145888797 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0029301
protein coding gene Chr5:138961355-138969283 (+)
CBA/J MGP_CBAJ_G0029861
protein coding gene Chr5:151568529-151576488 (+)
DBA/2J MGP_DBA2J_G0030012
protein coding gene Chr5:134503140-134511232 (+)
FVB/NJ MGP_FVBNJ_G0029967
protein coding gene Chr5:133653748-133662074 (+)
LP/J MGP_LPJ_G0030101
protein coding gene Chr5:141076879-141085992 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029999
protein coding gene Chr5:154559230-154567166 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030668
protein coding gene Chr5:138751815-138761033 (+)
PWK/PhJ MGP_PWKPhJ_G0029014
protein coding gene Chr5:133564543-133572850 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028850
protein coding gene Chr5:136303792-136311841 (+)
WSB/EiJ MGP_WSBEiJ_G0029374
protein coding gene Chr5:139486134-139494092 (+)



Homology
more
  • Human Ortholog
    UPK3B, uroplakin 3B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UPK3B, uroplakin 3B
  • Synonyms
    P35, UP3B, UPIIIB
  • Links
    NCBI Gene ID: 105375355
    neXtProt AC: NX_Q9BT76
    UniProt: Q9BT76

  • Chr Location
    chr7:76510525-76516522 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Mice homozygous for a knock-out allele exhibit normal heart, urinary bladder and upper urogenital system development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 100647 NCBI Gene Model | MGI Sequence Detail 6498 C57BL/6J ±  kb
transcript NM_175309 RefSeq | MGI Sequence Detail 2036 C57BL/6  
polypeptide Q80YF6 UniProt | EBI | MGI Sequence Detail 275 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    Genomic 2
    cDNA 6
    Primer pair 3
    Other 2

    Microarray probesets 2
Other
Accession IDs
less
MGI:2141008
References
more
  • Summaries
    All 44
    Developmental Gene Expression 11
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:345835 Qiu C, et al., A single-cell time-lapse of mouse prenatal development from gastrula to birth. Nature. 2024 Feb;626(8001):1084-1093

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory