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Lrrc8c Gene Detail
Summary
  • Symbol
    Lrrc8c
  • Name
    leucine rich repeat containing 8 family, member C
  • Synonyms
    E430036I04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140839
    NCBI Gene: 100604
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:105667254-105760884 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 50.68 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    583 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140839
 protein coding gene Chr5:105666850-105760884 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029826
 protein coding gene Chr5:107408913-107508185 (+)
A/J MGP_AJ_G0029790
 protein coding gene Chr5:103320491-103417166 (+)
AKR/J MGP_AKRJ_G0029735
 protein coding gene Chr5:106679433-106775290 (+)
BALB/cJ MGP_BALBcJ_G0029802
 protein coding gene Chr5:104466003-104561069 (+)
C3H/HeJ MGP_C3HHeJ_G0029524
 protein coding gene Chr5:107096752-107198198 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030256
 protein coding gene Chr5:111890660-111987725 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027491
 protein coding gene Chr5:98420257-98521566 (+)
CAST/EiJ MGP_CASTEiJ_G0028938
 protein coding gene Chr5:105990342-106090445 (+)
CBA/J MGP_CBAJ_G0029492
 protein coding gene Chr5:115605636-115721689 (+)
DBA/2J MGP_DBA2J_G0029638
 protein coding gene Chr5:103487377-103581337 (+)
FVB/NJ MGP_FVBNJ_G0029595
 protein coding gene Chr5:102199913-102294587 (+)
LP/J MGP_LPJ_G0029726
 protein coding gene Chr5:108024487-108120785 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029627
 protein coding gene Chr5:120669608-120766781 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030290
 protein coding gene Chr5:106212600-106308045 (+)
PWK/PhJ MGP_PWKPhJ_G0028651
 protein coding gene Chr5:101953580-102052698 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028489
 protein coding gene Chr5:103693552-103798578 (+)
WSB/EiJ MGP_WSBEiJ_G0029011
 protein coding gene Chr5:106528072-106626194 (+)



Homology
more
  • Human Ortholog
    LRRC8C, leucine rich repeat containing 8 VRAC subunit C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRC8C, leucine rich repeat containing 8 VRAC subunit C
  • Synonyms
    AD158, FAD158
  • Links
    NCBI Gene ID: 84230
    neXtProt AC: NX_Q8TDW0
    UniProt: Q8TDW0

  • Chr Location
    1p22.2; chr1:89615824-89769903 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a reduction in body weight, white adipose tissue weight, and insulin resistance on a high-fat diet, indicating protection from diet-induced obesity and insulin resistance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    11
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054720 Ensembl Gene Model | MGI Sequence Detail 93631 C57BL/6J ±  kb
    transcript ENSMUST00000067924 Ensembl | MGI Sequence Detail 6976 Not Applicable  
    polypeptide ENSMUSP00000066015 Ensembl | MGI Sequence Detail 803 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:333948 Lopez-Cayuqueo KI, et al., Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy. J Am Soc Nephrol. 2022 Aug;33(8):1528-1545
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory