Oas1d MGI Mouse Gene Detail - MGI:2140770 - 2'-5' oligoadenylate synthetase 1D

Symbol

Oas1d
Name

2'-5' oligoadenylate synthetase 1D

Feature Type

protein coding gene
IDs

MGI:2140770
NCBI Gene: 100535
Alliance

gene page

Sequence Map

Chr5:121052881-121059711 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 60.87 cM, cytoband F
Mapping Data

4 experiments

SNPs within 2kb

1 from dbSNP Build 142
Strain Annotations

8

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2140770	protein coding gene	Chr5:121052599-121059715 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030020	protein coding gene	Chr5:124344347-124353682 (+)
A/J	MGP_AJ_G0029985	protein coding gene	Chr5:119200774-119207394 (+)
AKR/J	no annotation
BALB/cJ	MGP_BALBcJ_G0029996	protein coding gene	Chr5:120625409-120632029 (+)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0030449	protein coding gene	Chr5:129061642-129066770 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	MGP_FVBNJ_G0029790	protein coding gene	Chr5:118241467-118248579 (+)
LP/J	MGP_LPJ_G0029922	protein coding gene	Chr5:124862438-124869095 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0030490	protein coding gene	Chr5:122599510-122606755 (+)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

OAS1, 2'-5'-oligoadenylate synthetase 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OAS1, 2'-5'-oligoadenylate synthetase 1
Synonyms

E18/E16, IFI-4, IMD100, OIAS, OIASI
Links

HGNC:8086

NCBI Gene ID: 4938

neXtProt AC: NX_P00973

UniProt: P00973
Chr Location

12q24.13; chr12:112905856-112933219 (+) GRCh38

MGI Vertebrate Homology

Oas1d stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: OAS1
Gene Tree

Oas1d

Diseases

1 with human OAS1 associations

				Human Disease	Mouse Models
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Oas1d
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null females exhibit reduced fertility due to defects in ovarian follicle development and decreased efficiency of ovulation.

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All GO Annotations

47
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

723
Tissues

12
cDNA Data

82
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

27
RefSeq

2
UniProt

2
CCDS

CCDS19631.1

Ensembl

ENSMUSG00000032623 (Evidence)
NCBI Gene

100535

			Length	Strain/Species	Flank
genomic	100535	NCBI Gene Model \| MGI Sequence Detail	6831	C57BL/6J	± kb
transcript	NM_133893	RefSeq \| MGI Sequence Detail	1750	ZRU/MplStud
polypeptide	Q8VI95	UniProt \| EBI \| MGI Sequence Detail	361	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal

IPR043519 Nucleotidyltransferase superfamily

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All nucleic 84

Genomic 1

cDNA 82

Primer pair 1

Microarray probesets 3

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MGI:2141327

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 11
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:192649 Kristiansen H, et al., The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities. J Interferon Cytokine Res. 2011 Jan;31(1):41-7

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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