Nhsl3 MGI Mouse Gene Detail - MGI:2140651

Symbol

Nhsl3
Name

NHS like 3
Synonyms

C77080, mKIAA1522

Feature Type

protein coding gene
IDs

MGI:2140651
NCBI Gene: 97130
Alliance

genome feature page
Transcription Start Sites

14 TSS

Sequence Map

Chr4:129113371-129155194 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 63.11 cM
Mapping Data

1 experiment

SNPs within 2kb

732 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2140651	protein coding gene	Chr4:129113371-129155197 (-)
129S1/SvImJ	ENSMUSG00200020929	protein coding gene	Chr4:122547820-122589911 (-)
A/J	ENSMUSG00195037736	protein coding gene	Chr4:123890194-123932059 (-)
AKR/J	ENSMUSG00220036835	protein coding gene	Chr4:122881380-122923241 (-)
BALB/cJ	ENSMUSG00180039035	protein coding gene	Chr4:121523884-121565737 (-)
C3H/HeJ	ENSMUSG00175032538	protein coding gene	Chr4:122536513-122578363 (-)
C57BL/6NJ	ENSMUSG00215052001	protein coding gene	Chr4:124037588-124079427 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026514	protein coding gene	Chr4:119020749-119065499 (-)
CAST/EiJ	ENSTCUG00005042893	protein coding gene	Chr4:123416574-123459401 (-)
CBA/J	ENSMUSG00210053848	protein coding gene	Chr4:122165311-122207166 (-)
DBA/2J	ENSMUSG00185046925	protein coding gene	Chr4:123697897-123739759 (-)
FVB/NJ	ENSMUSG00205012054	protein coding gene	Chr4:121925140-121967015 (-)
JF1/MsJ	ENSUMUG00000021461	protein coding gene	Chr4:124336860-124379845 (-)
LP/J	ENSMUSG00230037372	protein coding gene	Chr4:127485288-127527370 (-)
NOD/ShiLtJ	ENSMUSG00190037112	protein coding gene	Chr4:121929798-121971680 (-)
NZO/HlLtJ	ENSMUSG00225024846	protein coding gene	Chr4:133408821-133450682 (-)
PWK/PhJ	ENSLUMG00010040091	protein coding gene	Chr4:121378255-121421280 (-)
SPRET/EiJ	ENSMSPG00010042741	protein coding gene	Chr4:123451377-123480393 (-)
WSB/EiJ	ENSIUOG00005037412	protein coding gene	Chr4:121781046-121826915 (-)

Human Ortholog

NHSL3, NHS like 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NHSL3, NHS like 3
Synonyms

KIAA1522
Links

HGNC:29301

NCBI Gene ID: 57648

UniProt: Q9P206
Chr Location

1p35.1; chr1:32741696-32774970 (+) GRCh38

MGI Vertebrate Homology

Nhsl3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NHSL3
Gene Tree

Nhsl3

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Phenotype Summary

15 phenotype references

All Mutations and Alleles

80
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

71
Radiation induced

1
Targeted

4
Genomic Mutations

4 involving Nhsl3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

113 strains or lines available

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All GO Annotations

5
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

98

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nhsl3

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All Sequences

57
RefSeq

8
UniProt

3
CCDS

CCDS18686.1, CCDS71474.1, CCDS71475.1

Ensembl

ENSMUSG00000050390 (Evidence)
NCBI Gene

97130

			Length	Strain/Species	Flank
genomic	97130	NCBI Gene Model \| MGI Sequence Detail	41824	C57BL/6J	± kb
transcript	NM_001033189	RefSeq \| MGI Sequence Detail	5226	C57BL/6
polypeptide	A2A7S8	UniProt \| EBI \| MGI Sequence Detail	1013	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000060124 NHS-like protein 3

(term hierarchy)
InterPro Domains

IPR024845 Actin remodeling regulator NHS-like
GlyGen

A2A7S8 2 sites, 1 O-linked glycan (1 site)

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All nucleic 98

cDNA 98

Microarray probesets 4

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MGI:7525403

Summaries

All 39

Gene Ontology 3

Phenotypes 15
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Nhsl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr43488	Chr4:129155187-129155199 (-)	1 bp
Tssr43487	Chr4:129142224-129142291 (-)	12,936 bp
Tssr43486	Chr4:129142208-129142223 (-)	12,978 bp
Tssr43485	Chr4:129133005-129133021 (-)	22,181 bp
Tssr43484	Chr4:129132958-129132987 (-)	22,221 bp
Tssr43483	Chr4:129125443-129125454 (-)	29,745 bp
Tssr43482	Chr4:129124603-129124623 (-)	30,581 bp
Tssr43481	Chr4:129122368-129122385 (-)	32,817 bp
Tssr43480	Chr4:129121676-129121716 (-)	33,498 bp
Tssr43479	Chr4:129121650-129121672 (-)	33,533 bp
Tssr43478	Chr4:129117038-129117049 (-)	38,150 bp
Tssr43477	Chr4:129116931-129116946 (-)	38,255 bp
Tssr43476	Chr4:129116509-129116526 (-)	38,676 bp
Tssr43475	Chr4:129116170-129116184 (-)	39,017 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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