Tent5b MGI Mouse Gene Detail - MGI:2140500 - terminal nucleotidyltransferase 5B

Symbol

Tent5b
Name

terminal nucleotidyltransferase 5B
Synonyms

4732473B16Rik, Fam46b

Feature Type

protein coding gene
IDs

MGI:2140500
NCBI Gene: 100342
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr4:133207443-133215249 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 66.25 cM
Mapping Data

2 experiments

SNPs within 2kb

236 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2140500	protein coding gene	Chr4:133207443-133215251 (+)
129S1/SvImJ	ENSMUSG00200019510	protein coding gene	Chr4:126645719-126653561 (+)
A/J	ENSMUSG00195039977	protein coding gene	Chr4:127980972-127988829 (+)
AKR/J	ENSMUSG00220045946	protein coding gene	Chr4:126972746-126980607 (+)
BALB/cJ	ENSMUSG00180047183	protein coding gene	Chr4:125614742-125622591 (+)
C3H/HeJ	ENSMUSG00175040018	protein coding gene	Chr4:126627008-126634865 (+)
C57BL/6NJ	ENSMUSG00215050976	protein coding gene	Chr4:128138213-128146019 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026589	protein coding gene	Chr4:123129082-123136854 (+)
CAST/EiJ	ENSTCUG00005045411	protein coding gene	Chr4:127531087-127539131 (+)
CBA/J	ENSMUSG00210053104	protein coding gene	Chr4:126255987-126263844 (+)
DBA/2J	ENSMUSG00185052201	protein coding gene	Chr4:127788259-127796116 (+)
FVB/NJ	ENSMUSG00205045647	protein coding gene	Chr4:126033828-126041679 (+)
JF1/MsJ	ENSUMUG00000017936	protein coding gene	Chr4:128459482-128467285 (+)
LP/J	ENSMUSG00230035045	protein coding gene	Chr4:131584123-131591965 (+)
NOD/ShiLtJ	ENSMUSG00190030472	protein coding gene	Chr4:126020626-126028479 (+)
NZO/HlLtJ	ENSMUSG00225024970	protein coding gene	Chr4:137504256-137512062 (+)
PWK/PhJ	ENSLUMG00010038189	protein coding gene	Chr4:125472202-125480040 (+)
SPRET/EiJ	ENSMSPG00010039857	protein coding gene	Chr4:127542460-127550161 (+)
WSB/EiJ	ENSIUOG00005033915	protein coding gene	Chr4:125912602-125920460 (+)

Human Ortholog

TENT5B, terminal nucleotidyltransferase 5B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TENT5B, terminal nucleotidyltransferase 5B
Synonyms

FAM46, FAM46B
Links

HGNC:28273

NCBI Gene ID: 115572

UniProt: Q96A09
Chr Location

1p36.11; chr1:27005020-27012850 (-) GRCh38

MGI Vertebrate Homology

Tent5b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TENT5B
Gene Tree

Tent5b

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Phenotype Summary

7 phenotypes from 3 alleles in 2 genetic backgrounds
11 phenotypes from multigenic genotypes
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

3
Radiation induced

1
Targeted

3
Genomic Mutations

4 involving Tent5b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knock-out mice exhibit normal fertility.

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All GO Annotations

29
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

27

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tent5b

ZFIN tent5ba, tent5bb

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All Sequences

40
RefSeq

2
UniProt

1
CCDS

CCDS18748.1

Ensembl

ENSMUSG00000046694 (Evidence)
NCBI Gene

100342

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046694	Ensembl Gene Model \| MGI Sequence Detail	7807	C57BL/6J	± kb
transcript	ENSMUST00000051676	Ensembl \| MGI Sequence Detail	2287	Not Applicable
polypeptide	ENSMUSP00000056015	Ensembl \| MGI Sequence Detail	427	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030648 terminal nucleotidyltransferase 5B

(term hierarchy)
EC

2.7.7.19
InterPro Domains

IPR012937 Terminal nucleotidyltransferase
GlyGen

Q8C152 1 site

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All nucleic 27

cDNA 27

Microarray probesets 3

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MGI:2140502, MGI:6155753

Summaries

All 35

Gene Ontology 9

Phenotypes 6
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:360869 Brouze M, et al., TENT5-mediated polyadenylation of mRNAs encoding secreted proteins is essential for gametogenesis in mice. Nat Commun. 2024 Jun 22;15(1):5331

TSS for Tent5b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39485	Chr4:133207437-133207460 (+)	6 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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