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Pafah2 Gene Detail
Summary
  • Symbol
    Pafah2
  • Name
    platelet-activating factor acetylhydrolase 2
  • Synonyms
    2310074E22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140321
    NCBI Gene: 100163
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:134123631-134154723 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 66.68 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    401 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140321
protein coding gene Chr4:134123631-134154724 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028926
protein coding gene Chr4:136752050-136782909 (+)
A/J MGP_AJ_G0028885
protein coding gene Chr4:130993479-131024213 (+)
AKR/J MGP_AKRJ_G0028837
protein coding gene Chr4:134751589-134782080 (+)
BALB/cJ MGP_BALBcJ_G0028909
protein coding gene Chr4:131634666-131666268 (+)
C3H/HeJ MGP_C3HHeJ_G0028623
protein coding gene Chr4:134988682-135019753 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029350
protein coding gene Chr4:141683272-141717550 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026621
protein coding gene Chr4:124052492-124083731 (+)
CAST/EiJ MGP_CASTEiJ_G0028055
protein coding gene Chr4:133114542-133147877 (+)
CBA/J MGP_CBAJ_G0028588
protein coding gene Chr4:145404140-145447686 (+)
DBA/2J MGP_DBA2J_G0028737
protein coding gene Chr4:131416235-131445393 (+)
FVB/NJ MGP_FVBNJ_G0028704
protein coding gene Chr4:130307736-130342147 (+)
LP/J MGP_LPJ_G0028836
protein coding gene Chr4:136836724-136883671 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028730
protein coding gene Chr4:149895710-149927181 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029388
protein coding gene Chr4:135191421-135222658 (+)
PWK/PhJ MGP_PWKPhJ_G0027775
protein coding gene Chr4:128144135-128174386 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027601
protein coding gene Chr4:131001682-131037486 (+)
WSB/EiJ MGP_WSBEiJ_G0028133
protein coding gene Chr4:135347321-135383791 (+)



Homology
more
  • Human Ortholog
    PAFAH2, platelet activating factor acetylhydrolase 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAFAH2, platelet activating factor acetylhydrolase 2
  • Synonyms
    HSD-PLA2
  • Links
    NCBI Gene ID: 5051
    neXtProt AC: NX_Q99487
    UniProt: Q99487

  • Chr Location
    1p36.11; chr1:25959767-25998117 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased sensitivity to hepatic injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100163 NCBI Gene Model | MGI Sequence Detail 31093 C57BL/6J ±  kb
    transcript NM_001285872 RefSeq | MGI Sequence Detail 3194 C57BL/6  
    polypeptide Q8VDG7 UniProt | EBI | MGI Sequence Detail 390 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 67
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1919176
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:328505 Moriyama H, et al., Omega-3 fatty acid epoxides produced by PAF-AH2 in mast cells regulate pulmonary vascular remodeling. Nat Commun. 2022 May 31;13(1):3013

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/21/2024
    MGI 6.23
    The Jackson Laboratory