Mexis Gene Detail

Summary

• Symbol
  Mexis
• Name
  macrophage expressed LXRa(NR1H3)-dependent amplifier of Abca1 transcription lncRNA
• Synonyms
  AI427809, LOC381524

• Feature Type
  lncRNA gene
• IDs
  MGI:2140270
  NCBI Gene: 381524
• Alliance
  genome feature page

Location &
Maps

• Sequence Map
  Chr4:53261356-53270232 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 4, 28.60 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  435 from dbSNP Build 142
• Strain Annotations
  19

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2140270	lncRNA gene	Chr4:53261354-53339840 (-)
129S1/SvImJ	ENSMUSG00200003384	lncRNA gene	Chr4:49328659-49337535 (-)
A/J	ENSMUSG00195006553	lncRNA gene	Chr4:49748526-49757400 (-)
AKR/J	ENSMUSG00220002912	lncRNA gene	Chr4:49500380-49509258 (-)
BALB/cJ	ENSMUSG00180031062	lncRNA gene	Chr4:49335845-49344723 (-)
C3H/HeJ	ENSMUSG00175021175	lncRNA gene	Chr4:49486949-49495823 (-)
C57BL/6NJ	ENSMUSG00215025105	lncRNA gene	Chr4:49314587-49323463 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0005843	lincRNA gene	Chr4:46865474-46874346 (-)
CAST/EiJ	ENSTCUG00005039114	lncRNA gene	Chr4:49585118-49593904 (-)
CBA/J	ENSMUSG00210019667	lncRNA gene	Chr4:49227024-49235900 (-)
DBA/2J	ENSMUSG00185034105	lncRNA gene	Chr4:49575594-49584470 (-)
FVB/NJ	ENSMUSG00205023022	lncRNA gene	Chr4:48839996-48848874 (-)
JF1/MsJ	ENSUMUG00000038783	lncRNA gene	Chr4:49773170-49781967 (-)
LP/J	ENSMUSG00230005200	lncRNA gene	Chr4:53131151-53140027 (-)
NOD/ShiLtJ	ENSMUSG00190026060	lncRNA gene	Chr4:49411851-49420729 (-)
NZO/HlLtJ	ENSMUSG00225003282	lncRNA gene	Chr4:57727366-57736236 (-)
PWK/PhJ	ENSLUMG00010012716	lncRNA gene	Chr4:48700405-48709199 (-)
SPRET/EiJ	ENSMSPG00010010046	lncRNA gene	Chr4:49869101-49877837 (-)
WSB/EiJ	ENSIUOG00005004543	lncRNA gene	Chr4:49191961-49200839 (-)

Homology

• Gene Tree
  Mexis
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 1 allele in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  1 strains or lines available

Homozygous knockout affects macrophage cholesterol metabolism and increases atherosclerosis susceptibility in mice fed Western diet.

Expression

• Assay Results
  597
• cDNA Data
  9

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  67
• RefSeq
  3
• UniProt
  1

• Ensembl
  ENSMUSG00000086712 (Evidence)
• NCBI Gene
  381524

Representative Sequences			Length	Strain/Species
genomic	381524	NCBI Gene Model | MGI Sequence Detail	8877	C57BL/6J
transcript	NR_033140	RefSeq | MGI Sequence Detail	2123	C57BL/6
polypeptide	Q3TAG4	UniProt | EBI | MGI Sequence Detail	104	Not Applicable

Protein
Information

• UniProt
  1 Sequence

Molecular
Reagents

• All nucleic 9

  cDNA 9

  
  

  Microarray probesets 1

Other
Accession IDs

MGI:2686505, MGI:6402049

References

• Summaries
  All 15

  Phenotypes 1
• Earliest
  J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
• Latest
  J:264834 Sallam T, et al., Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA. Nat Med. 2018 Mar;24(3):304-312