Golga2 MGI Mouse Gene Detail - MGI:2139395

Symbol

Golga2
Name

golgin A2
Synonyms

GM130

Feature Type

protein coding gene
IDs

MGI:2139395
NCBI Gene: 99412
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:32178299-32197925 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 22.09 cM
Mapping Data

1 experiment

SNPs within 2kb

350 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2139395	protein coding gene	Chr2:32177396-32197933 (+)
129S1/SvImJ	ENSMUSG00200052412	protein coding gene	Chr2:29149614-29170152 (+)
A/J	ENSMUSG00195049053	protein coding gene	Chr2:29251656-29271515 (+)
AKR/J	ENSMUSG00220053395	protein coding gene	Chr2:29369563-29389418 (+)
BALB/cJ	ENSMUSG00180051271	protein coding gene	Chr2:29266344-29286203 (+)
C3H/HeJ	ENSMUSG00175053319	protein coding gene	Chr2:29232751-29252607 (+)
C57BL/6NJ	ENSMUSG00215045415	protein coding gene	Chr2:29298254-29318110 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023428	protein coding gene	Chr2:28157824-28178657 (+)
CAST/EiJ	ENSTCUG00005052648	protein coding gene	Chr2:28978983-28998829 (+)
CBA/J	ENSMUSG00210015618	protein coding gene	Chr2:29305297-29325158 (+)
DBA/2J	ENSMUSG00185051784	protein coding gene	Chr2:29164926-29184784 (+)
FVB/NJ	ENSMUSG00205048302	protein coding gene	Chr2:29011670-29031531 (+)
JF1/MsJ	ENSUMUG00000026426	protein coding gene	Chr2:29057961-29076689 (+)
LP/J	ENSMUSG00230040685	protein coding gene	Chr2:31085846-31105703 (+)
NOD/ShiLtJ	ENSMUSG00190048582	protein coding gene	Chr2:29266106-29285962 (+)
NZO/HlLtJ	ENSMUSG00225007682	protein coding gene	Chr2:38842067-38862605 (+)
PWK/PhJ	ENSLUMG00010051267	protein coding gene	Chr2:29146212-29166104 (+)
SPRET/EiJ	ENSMSPG00010036720	protein coding gene	Chr2:29852694-29872414 (+)
WSB/EiJ	ENSIUOG00005050108	protein coding gene	Chr2:29114568-29134415 (+)

Human Ortholog

GOLGA2, golgin A2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GOLGA2, golgin A2
Synonyms

DEDHMB, GM130
Links

HGNC:4425

NCBI Gene ID: 2801

UniProt: Q08379
Chr Location

9q34.11; chr9:128255829-128276026 (-) GRCh38

MGI Vertebrate Homology

Golga2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GOLGA2
Gene Tree

Golga2

less

Phenotype Summary

48 phenotypes from 3 alleles in 5 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

4
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

55 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele show premature death, developmental delay, ataxia, Purkinje neuron loss, and male infertility with globozoospermia and lack of acrosome formation. Homozygotes for a different null allele show partial prenatal lethality and autophagy-induced liver and lung fibrosis.

less

All GO Annotations

65
GO References

46

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

37
cDNA Data

115
Literature Summary

102

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase golga2

ZFIN golga2

less

All Sequences

83
RefSeq

16
UniProt

10
CCDS

CCDS38100.1, CCDS38101.1

Ensembl

ENSMUSG00000002546 (Evidence)
NCBI Gene

99412

			Length	Strain/Species	Flank
genomic	99412	NCBI Gene Model \| MGI Sequence Detail	19627	C57BL/6J	± kb
transcript	NM_133852	RefSeq \| MGI Sequence Detail	4361	C57BL/6
polypeptide	Q921M4	UniProt \| EBI \| MGI Sequence Detail	999	Not Applicable

less

UniProt

10 Sequences
Protein Ontology

PR:000008131 golgin subfamily A member 2

(term hierarchy)
InterPro Domains

IPR024858 Golgin subfamily A

IPR043976 Golgin subfamily A, conserved domain

IPR043937 Golgin subfamily A , C-terminal binding motif
GlyGen

Q921M4 3 sites, 1 O-linked glycan (2 sites)

less

All nucleic 115

cDNA 115

Antibodies 11

Microarray probesets 3

Summaries

All 181

Developmental Gene Expression 102

Gene Ontology 46

Phenotypes 13
Earliest

J:65653 Wertz K, et al., Large-scale screen for genes involved in gonad development. Mech Dev. 2000 Nov;98(1-2):51-70
Latest

J:384897 Hu FJ, et al., Heterogeneous nuclear ribonucleoprotein L orchestrates alternative splicing critical for primordial follicle formation. J Adv Res. 2026 Feb 19;

TSS for Golga2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17259	Chr2:32178256-32178268 (+)	-37 bp
Tssr17260	Chr2:32178289-32178306 (+)	-1 bp
Tssr17261	Chr2:32178329-32178365 (+)	48 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24