Tm9sf4 MGI Mouse Gene Detail - MGI:2139220 - transmembrane 9 superfamily member 4

Symbol

Tm9sf4
Name

transmembrane 9 superfamily member 4
Synonyms

mKIAA0255

Feature Type

protein coding gene
IDs

MGI:2139220
NCBI Gene: 99237
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:153003223-153052386 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 75.41 cM
Mapping Data

1 experiment

SNPs within 2kb

286 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2139220	protein coding gene	Chr2:152999279-153052386 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026688	protein coding gene	Chr2:157774126-157825801 (+)
A/J	MGP_AJ_G0026654	protein coding gene	Chr2:151463228-151513732 (+)
AKR/J	MGP_AKRJ_G0026624	protein coding gene	Chr2:155889293-155940606 (+)
BALB/cJ	MGP_BALBcJ_G0026663	protein coding gene	Chr2:151773108-151824131 (+)
C3H/HeJ	MGP_C3HHeJ_G0026406	protein coding gene	Chr2:156260962-156318344 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027112	protein coding gene	Chr2:162346575-162414604 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024483	protein coding gene	Chr2:145046475-145092828 (+)
CAST/EiJ	MGP_CASTEiJ_G0025867	protein coding gene	Chr2:156516547-156571337 (+)
CBA/J	MGP_CBAJ_G0026384	protein coding gene	Chr2:168329165-168382695 (+)
DBA/2J	MGP_DBA2J_G0026520	protein coding gene	Chr2:150672539-150721565 (+)
FVB/NJ	MGP_FVBNJ_G0026486	protein coding gene	Chr2:149134908-149190460 (+)
LP/J	MGP_LPJ_G0026624	protein coding gene	Chr2:157918597-157974403 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026507	protein coding gene	Chr2:172373831-172428183 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027168	protein coding gene	Chr2:155788446-155843577 (+)
PWK/PhJ	MGP_PWKPhJ_G0025601	protein coding gene	Chr2:150204890-150256063 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025404	protein coding gene	Chr2:154622911-154672284 (+)
WSB/EiJ	MGP_WSBEiJ_G0025937	protein coding gene	Chr2:156685785-156738137 (+)

Human Ortholog

TM9SF4, transmembrane 9 superfamily member 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TM9SF4, transmembrane 9 superfamily member 4
Synonyms

dJ836N17.2
Links

HGNC:30797

NCBI Gene ID: 9777

neXtProt AC: NX_Q92544

UniProt: Q92544
Chr Location

20q11.21; chr20:32109506-32167258 (+) GRCh38.p7

Alliance of Genome Resources

Tm9sf4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TM9SF4
Gene Tree

Tm9sf4

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

106
Endonuclease-mediated

1
Gene trapped

103
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

110 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants exhibit abnormal hair follicles and sebaceous glands, vertebrae and rib abnormalities, and increased circulating cholesterol, calcium, albumin, and total protein levels.

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All GO Annotations

12
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

748
Tissues

28
cDNA Data

139
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tm9sf4

ZFIN tm9sf4

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Tm9sf4 interacts with 222 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

76
RefSeq

8
UniProt

4
CCDS

CCDS16906.1

Ensembl

ENSMUSG00000068040 (Evidence)
NCBI Gene

99237

			Length	Strain/Species	Flank
genomic	ENSMUSG00000068040	Ensembl Gene Model \| MGI Sequence Detail	49164	C57BL/6J	± kb
transcript	ENSMUST00000089027	Ensembl \| MGI Sequence Detail	3896	Not Applicable
polypeptide	ENSMUSP00000086422	Ensembl \| MGI Sequence Detail	643	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000032375 transmembrane 9 superfamily member 4

(term hierarchy)
InterPro Domains

IPR004240 Nonaspanin (TM9SF)

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All nucleic 139

cDNA 139

Microarray probesets 4

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MGI:2138821

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 13
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:264029 Sun L, et al., TM9SF4 is a novel factor promoting autophagic flux under amino acid starvation. Cell Death Differ. 2018 Feb;25(2):368-379

TSS for Tm9sf4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20873	Chr2:153003212-153003227 (+)	-3 bp
Tssr20874	Chr2:153003241-153003259 (+)	27 bp
Tssr20875	Chr2:153003444-153003473 (+)	236 bp
Tssr20876	Chr2:153003848-153003876 (+)	639 bp
Tssr20877	Chr2:153003878-153003896 (+)	664 bp
Tssr20878	Chr2:153033714-153033728 (+)	30,498 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 01/17/2023 MGI 6.22