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Gpr107 Gene Detail
Summary
  • Symbol
    Gpr107
  • Name
    G protein-coupled receptor 107
  • Synonyms
    mKIAA1624
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139054
    NCBI Gene: 277463
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:31042099-31106579 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 21.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    540 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139054
 protein coding gene Chr2:31042099-31108787 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025582
 protein coding gene Chr2:29463810-29535600 (+)
A/J MGP_AJ_G0025560
 protein coding gene Chr2:28263745-28324299 (+)
AKR/J MGP_AKRJ_G0025529
 protein coding gene Chr2:29225595-29286258 (+)
BALB/cJ MGP_BALBcJ_G0025556
 protein coding gene Chr2:28398159-28460990 (+)
C3H/HeJ MGP_C3HHeJ_G0025317
 protein coding gene Chr2:29158034-29225530 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026001
 protein coding gene Chr2:30415778-30487821 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023409
 protein coding gene Chr2:27026988-27093803 (+)
CAST/EiJ MGP_CASTEiJ_G0024779
 protein coding gene Chr2:29091949-29164158 (+)
CBA/J MGP_CBAJ_G0025294
 protein coding gene Chr2:31502957-31576909 (+)
DBA/2J MGP_DBA2J_G0025427
 protein coding gene Chr2:28039432-28101249 (+)
FVB/NJ MGP_FVBNJ_G0025390
 protein coding gene Chr2:27883145-27951609 (+)
LP/J MGP_LPJ_G0025513
 protein coding gene Chr2:29373473-29441531 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025420
 protein coding gene Chr2:31273594-31340539 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026059
 protein coding gene Chr2:29145087-29214679 (+)
PWK/PhJ MGP_PWKPhJ_G0024526
 protein coding gene Chr2:27926022-27995115 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024326
 protein coding gene Chr2:29286246-29356926 (+)
WSB/EiJ MGP_WSBEiJ_G0024847
 protein coding gene Chr2:29322328-29387771 (+)



Homology
more
  • Human Ortholog
    GPR107, G protein-coupled receptor 107
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR107, G protein-coupled receptor 107
  • Synonyms
    bA138E2.2, GCDRP, LUSTR1
  • Links
    NCBI Gene ID: 57720
    neXtProt AC: NX_Q5VW38
    UniProt: Q5VW38

  • Chr Location
    9q34.11; chr9:130053426-130140169 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes complete embryonic lethality during organogenesis, associated with reduced expression of genes implicated in the cubilin-megalin multi-ligand endocytic receptor complex. Homozygous null MEFs show defects in receptor-mediated endocytosis and recycling.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 277463 NCBI Gene Model | MGI Sequence Detail 64481 C57BL/6J ±  kb
    transcript NM_178760 RefSeq | MGI Sequence Detail 3926 C57BL/6  
    polypeptide Q8BUV8 UniProt | EBI | MGI Sequence Detail 551 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 5
    References
    more
    • Summaries
      All 37
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
    • Latest
      J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory