Gtf3c4 MGI Mouse Gene Detail - MGI:2138937 - general transcription factor IIIC, polypeptide 4

Symbol

Gtf3c4
Name

general transcription factor IIIC, polypeptide 4
Synonyms

KAT12

Feature Type

protein coding gene
IDs

MGI:2138937
NCBI Gene: 269252
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:28712311-28730372 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 19.38 cM
Mapping Data

2 experiments

SNPs within 2kb

64 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2138937	protein coding gene	Chr2:28712311-28730628 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025532	protein coding gene	Chr2:26908054-26926111 (-)
A/J	MGP_AJ_G0025509	protein coding gene	Chr2:25878932-25897000 (-)
AKR/J	MGP_AKRJ_G0025479	protein coding gene	Chr2:26735036-26753093 (-)
BALB/cJ	MGP_BALBcJ_G0025505	protein coding gene	Chr2:26000267-26018415 (-)
C3H/HeJ	MGP_C3HHeJ_G0025266	protein coding gene	Chr2:26657131-26675208 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025949	protein coding gene	Chr2:27799617-27819416 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023359	protein coding gene	Chr2:24694964-24713541 (-)
CAST/EiJ	MGP_CASTEiJ_G0024729	protein coding gene	Chr2:26566717-26584524 (-)
CBA/J	MGP_CBAJ_G0025244	protein coding gene	Chr2:28752584-28770641 (-)
DBA/2J	MGP_DBA2J_G0025377	protein coding gene	Chr2:25688296-25706362 (-)
FVB/NJ	MGP_FVBNJ_G0025339	protein coding gene	Chr2:25481795-25499855 (-)
LP/J	MGP_LPJ_G0025463	protein coding gene	Chr2:26849210-26867615 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025370	protein coding gene	Chr2:28756619-28776192 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026008	protein coding gene	Chr2:26653514-26671591 (-)
PWK/PhJ	MGP_PWKPhJ_G0024476	protein coding gene	Chr2:25500272-25519331 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024276	protein coding gene	Chr2:26786964-26804602 (-)
WSB/EiJ	MGP_WSBEiJ_G0024798	protein coding gene	Chr2:26787735-26806705 (-)

Human Ortholog

GTF3C4, general transcription factor IIIC subunit 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GTF3C4, general transcription factor IIIC subunit 4
Synonyms

KAT12, TF3C-delta, TFIII90, TFIIIC290, TFIIIC90, TFIIICDELTA
Links

HGNC:4667

NCBI Gene ID: 9329

neXtProt AC: NX_Q9UKN8

UniProt: Q9UKN8
Chr Location

9q34.13; chr9:132670035-132694955 (+) GRCh38

MGI Vertebrate Homology

Gtf3c4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GTF3C4
Gene Tree

Gtf3c4

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Phenotype Summary

6 phenotype references

All Mutations and Alleles

5
Gene trapped

2
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available

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All GO Annotations

11
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

168
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gtf3c4

ZFIN gtf3c4

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All Sequences

72
RefSeq

14
UniProt

5
CCDS

CCDS15847.1, CCDS50550.1

Ensembl

ENSMUSG00000035666 (Evidence)
NCBI Gene

269252

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035666	Ensembl Gene Model \| MGI Sequence Detail	18062	C57BL/6J	± kb
transcript	ENSMUST00000037117	Ensembl \| MGI Sequence Detail	6941	Not Applicable
polypeptide	ENSMUSP00000042265	Ensembl \| MGI Sequence Detail	817	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008328 general transcription factor 3C polypeptide 4

(term hierarchy)
EC

2.3.1.48
InterPro Domains

IPR045803 Domain of unknown function DUF5921

IPR044230 General transcription factor 3C polypeptide 4

IPR024761 Transcription factor IIIC, 90kDa subunit, N-terminal

IPR024764 Transcription factor IIIC, putative zinc-finger

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 168

cDNA 168

Microarray probesets 6

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MGI:2139146, MGI:2139163

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 6
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Gtf3c4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr23295	Chr2:28730286-28730370 (-)	44 bp
Tssr23294	Chr2:28730270-28730281 (-)	96 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23