Colgalt2 MGI Mouse Gene Detail - MGI:2138232 - collagen beta(1-O)galactosyltransferase 2

Symbol

Colgalt2
Name

collagen beta(1-O)galactosyltransferase 2
Synonyms

Glt25d2

Feature Type

protein coding gene
IDs

MGI:2138232
NCBI Gene: 269132
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:152275581-152386446 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 64.77 cM
Mapping Data

1 experiment

SNPs within 2kb

3548 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2138232	protein coding gene	Chr1:152275485-152386942 (+)
129S1/SvImJ	ENSMUSG00200002128	protein coding gene	Chr1:149727408-149829649 (+)
A/J	ENSMUSG00195013182	protein coding gene	Chr1:149093663-149204556 (+)
AKR/J	ENSMUSG00220004932	protein coding gene	Chr1:148899952-149000088 (+)
BALB/cJ	ENSMUSG00180031632	protein coding gene	Chr1:149323382-149434253 (+)
C3H/HeJ	ENSMUSG00175002808	protein coding gene	Chr1:149360284-149471175 (+)
C57BL/6NJ	ENSMUSG00215003361	protein coding gene	Chr1:149258369-149369237 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014699	protein coding gene	Chr1:143150356-143257141 (+)
CAST/EiJ	ENSTCUG00005005647	protein coding gene	Chr1:147890675-148001976 (+)
CBA/J	ENSMUSG00210033485	protein coding gene	Chr1:149264151-149375041 (+)
DBA/2J	ENSMUSG00185042556	protein coding gene	Chr1:153525696-153626907 (+)
FVB/NJ	ENSMUSG00205023601	protein coding gene	Chr1:148395935-148497155 (+)
JF1/MsJ	ENSUMUG00000013680	protein coding gene	Chr1:152703821-152803997 (+)
LP/J	ENSMUSG00230012528	protein coding gene	Chr1:153089198-153198471 (+)
NOD/ShiLtJ	ENSMUSG00190011991	protein coding gene	Chr1:149082128-149183371 (+)
NZO/HlLtJ	ENSMUSG00225005785	protein coding gene	Chr1:156774743-156875383 (+)
PWK/PhJ	ENSLUMG00010026584	protein coding gene	Chr1:148043687-148152005 (+)
SPRET/EiJ	ENSMSPG00010005133	protein coding gene	Chr1:151392589-151490477 (+)
WSB/EiJ	ENSIUOG00005021197	protein coding gene	Chr1:148669122-148779853 (+)

Human Ortholog

COLGALT2, collagen beta(1-O)galactosyltransferase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COLGALT2, collagen beta(1-O)galactosyltransferase 2
Synonyms

C1orf17, ColGalT 2, GLT25D2
Links

HGNC:16790

NCBI Gene ID: 23127

UniProt: Q8IYK4
Chr Location

1q25.3; chr1:183929662-184037729 (-) GRCh38

MGI Vertebrate Homology

Colgalt2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: COLGALT2
Gene Tree

Colgalt2

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Phenotype Summary

20 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Gene trapped

1
Targeted

4
Genomic Mutations

2 involving Colgalt2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

56 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice exhibit more extensive hepatocellular injury following concanavalin A challenge, with increased levels of interleukins, increased CD25+CD69- subset and decreased CD25-CD69+ subset of CD4+ T cells, and increased CD4+ T cell apoptosis.

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

123
cDNA Data

14
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA COLGALT2

Xenbase colgalt2

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All Sequences

41
RefSeq

6
UniProt

2
CCDS

CCDS15364.1

Ensembl

ENSMUSG00000032649 (Evidence)
NCBI Gene

269132

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032649	Ensembl Gene Model \| MGI Sequence Detail	110866	C57BL/6J	± kb
transcript	ENSMUST00000044311	Ensembl \| MGI Sequence Detail	4093	Not Applicable
polypeptide	ENSMUSP00000037532	Ensembl \| MGI Sequence Detail	625	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030431 procollagen galactosyltransferase 2

(term hierarchy)
EC

2.4.1.50
InterPro Domains

IPR050757 Collagen-modifying Glycosyltransferase 25

IPR002654 Glycosyl transferase, family 25

IPR029044 Nucleotide-diphospho-sugar transferases
GlyGen

Q6NVG7 4 sites, 1 N-linked glycan (1 site)

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 11
Earliest

J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
Latest

J:310396 Yang J, et al., Collagen beta(1-O) galactosyltransferase 2 deficiency contributes to lipodystrophy and aggravates NAFLD related to HMW adiponectin in mice. Metabolism. 2021 Jul;120:154777

TSS for Colgalt2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9408	Chr1:152275553-152275560 (+)	-24 bp
Tssr9409	Chr1:152275575-152275632 (+)	23 bp
Tssr9410	Chr1:152275633-152275642 (+)	57 bp
Tssr9411	Chr1:152275646-152275659 (+)	72 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24