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Utp25 Gene Detail
Summary
  • Symbol
    Utp25
  • Name
    UTP25 small subunit processome component
  • Synonyms
    AA408296, Diexf, mDef
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138080
    NCBI Gene: 215193
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:192786707-192812603 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 97.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    229 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138080
protein coding gene Chr1:192773412-192812603 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016957
protein coding gene Chr1:200175058-200215942 (-)
A/J MGP_AJ_G0016936
protein coding gene Chr1:191939145-191979965 (-)
AKR/J MGP_AKRJ_G0016901
protein coding gene Chr1:197667609-197706814 (-)
BALB/cJ MGP_BALBcJ_G0016894
protein coding gene Chr1:192636690-192676229 (-)
C3H/HeJ MGP_C3HHeJ_G0016718
protein coding gene Chr1:198503487-198543599 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017357
protein coding gene Chr1:206541323-206583236 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015064
protein coding gene Chr1:182812265-182853071 (-)
CAST/EiJ MGP_CASTEiJ_G0016301
protein coding gene Chr1:198083269-198125845 (-)
CBA/J MGP_CBAJ_G0016692
protein coding gene Chr1:214174337-214215780 (-)
DBA/2J MGP_DBA2J_G0016798
protein coding gene Chr1:190658135-190697708 (-)
FVB/NJ MGP_FVBNJ_G0016794
protein coding gene Chr1:188781687-188822926 (-)
LP/J MGP_LPJ_G0016873
protein coding gene Chr1:201353112-201394759 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016826
protein coding gene Chr1:220809101-220852682 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017394
protein coding gene Chr1:197480832-197523488 (-)
PWK/PhJ MGP_PWKPhJ_G0016088
protein coding gene Chr1:189979364-190019820 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015864
protein coding gene Chr1:196511967-196554504 (-)
WSB/EiJ MGP_WSBEiJ_G0016363
protein coding gene Chr1:197773020-197813756 (-)



Homology
more
  • Human Ortholog
    UTP25, UTP25 small subunit processome component
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UTP25, UTP25 small subunit processome component
  • Synonyms
    C1orf107, DEF, DIEXF, DJ434O14.5
  • Links
    NCBI Gene ID: 27042
    neXtProt AC: NX_Q68CQ4
    UniProt: Q68CQ4

  • Chr Location
    1q32.2; chr1:209827972-209857565 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout is embryonic lethal around the implantation stage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 215193 NCBI Gene Model | MGI Sequence Detail 25897 C57BL/6J ±  kb
transcript NM_001368818 RefSeq | MGI Sequence Detail 5729 C57BL/6  
polypeptide Q8BTT6 UniProt | EBI | MGI Sequence Detail 772 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000006377 digestive organ expansion factor
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR010678 U3 small nucleolar RNA-associated protein 25
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 6
Other
Accession IDs
less
MGI:2138538
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:338390 Wei J, et al., Hepatic depletion of nucleolar protein mDEF causes excessive mitochondrial copper accumulation associated with p53 and NRF1 activation. iScience. 2023 Jul 21;26(7):107220

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory