Sfxn2 MGI Mouse Gene Detail - MGI:2137678

Symbol

Sfxn2
Name

sideroflexin 2
Synonyms

F630107H02Rik

Feature Type

protein coding gene
IDs

MGI:2137678
NCBI Gene: 94279
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr19:46561798-46585340 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 38.96 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

192 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2137678	protein coding gene	Chr19:46561798-46586505 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025212	protein coding gene	Chr19:46306017-46337599 (+)
A/J	MGP_AJ_G0025188	protein coding gene	Chr19:43994922-44019249 (+)
AKR/J	MGP_AKRJ_G0025157	protein coding gene	Chr19:45426936-45454304 (+)
BALB/cJ	MGP_BALBcJ_G0025183	protein coding gene	Chr19:44050945-44075062 (+)
C3H/HeJ	MGP_C3HHeJ_G0024943	protein coding gene	Chr19:45594538-45632499 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025626	protein coding gene	Chr19:47422132-47451324 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023040	protein coding gene	Chr19:43240157-43264349 (+)
CAST/EiJ	MGP_CASTEiJ_G0024408	protein coding gene	Chr19:45409778-45439444 (+)
CBA/J	MGP_CBAJ_G0024923	protein coding gene	Chr19:49814671-49841705 (+)
DBA/2J	MGP_DBA2J_G0025055	protein coding gene	Chr19:43814232-43840383 (+)
FVB/NJ	MGP_FVBNJ_G0025016	protein coding gene	Chr19:43599340-43624564 (+)
LP/J	MGP_LPJ_G0025141	protein coding gene	Chr19:46199791-46225332 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025047	protein coding gene	Chr19:49146431-49183691 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025684	protein coding gene	Chr19:45549420-45565856 (+)
PWK/PhJ	MGP_PWKPhJ_G0024157	protein coding gene	Chr19:43767673-43792959 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023961	protein coding gene	Chr19:44186896-44210488 (+)
WSB/EiJ	MGP_WSBEiJ_G0024478	protein coding gene	Chr19:45687507-45714065 (+)

Human Ortholog

SFXN2, sideroflexin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SFXN2, sideroflexin 2
Synonyms

SLC56A2
Links

HGNC:16086

NCBI Gene ID: 118980

neXtProt AC: NX_Q96NB2

UniProt: Q96NB2
Chr Location

10q24.32; chr10:102714538-102743492 (+) GRCh38

MGI Vertebrate Homology

Sfxn2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SFXN2
Gene Tree

Sfxn2

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Phenotype Summary

5 phenotype references

All Mutations and Alleles

5
Endonuclease-mediated

1
Gene trapped

2
Targeted

2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

19 strains or lines available

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All GO Annotations

13
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

12

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sfxn2

ZFIN sfxn2

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All Sequences

49
RefSeq

4
UniProt

3
CCDS

CCDS29880.1

Ensembl

ENSMUSG00000025036 (Evidence)
NCBI Gene

94279

			Length	Strain/Species	Flank
genomic	94279	NCBI Gene Model \| MGI Sequence Detail	23543	C57BL/6J	± kb
transcript	NM_053196	RefSeq \| MGI Sequence Detail	3228	C57BL/6
polypeptide	Q925N2	UniProt \| EBI \| MGI Sequence Detail	322	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014777 sideroflexin-2

(term hierarchy)
InterPro Domains

IPR004686 Tricarboxylate/iron carrier

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All nucleic 12

cDNA 12

Microarray probesets 8

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MGI:2147791

Summaries

All 35

Gene Ontology 10

Phenotypes 5
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Sfxn2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156783	Chr19:46561801-46561860 (+)	33 bp
Tssr156784	Chr19:46561861-46561875 (+)	70 bp
Tssr156785	Chr19:46583562-46583565 (+)	21,766 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23