Niban1 MGI Mouse Gene Detail - MGI:2137237 - niban apoptosis regulator 1

Symbol

Niban1
Name

niban apoptosis regulator 1
Synonyms

Fam129a, Niban

Feature Type

protein coding gene
IDs

MGI:2137237
NCBI Gene: 63913
Alliance

genome feature page
Transcription Start Sites

10 TSS

Sequence Map

Chr1:151447215-151597690 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 64.21 cM
Mapping Data

1 experiment

SNPs within 2kb

4694 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2137237	protein coding gene	Chr1:151446937-151597690 (+)
129S1/SvImJ	ENSMUSG00200002215	protein coding gene	Chr1:148892314-149048233 (+)
A/J	ENSMUSG00195013812	protein coding gene	Chr1:148258346-148414278 (+)
AKR/J	ENSMUSG00220005107	protein coding gene	Chr1:148065129-148218223 (+)
BALB/cJ	ENSMUSG00180029965	protein coding gene	Chr1:148493009-148644243 (+)
C3H/HeJ	ENSMUSG00175002742	protein coding gene	Chr1:148522072-148677989 (+)
C57BL/6NJ	ENSMUSG00215003327	protein coding gene	Chr1:148428716-148579943 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014695	protein coding gene	Chr1:142333378-142486395 (+)
CAST/EiJ	ENSTCUG00005005357	protein coding gene	Chr1:147046061-147198309 (+)
CBA/J	ENSMUSG00210031115	protein coding gene	Chr1:148428932-148584845 (+)
DBA/2J	ENSMUSG00185044992	protein coding gene	Chr1:152700371-152851989 (+)
FVB/NJ	ENSMUSG00205024618	protein coding gene	Chr1:147571195-147722812 (+)
JF1/MsJ	ENSUMUG00000011824	protein coding gene	Chr1:151867007-152020104 (+)
LP/J	ENSMUSG00230000264	protein coding gene	Chr1:152254226-152407651 (+)
NOD/ShiLtJ	ENSMUSG00190011525	protein coding gene	Chr1:148256415-148407452 (+)
NZO/HlLtJ	ENSMUSG00225005017	protein coding gene	Chr1:155941830-156093044 (+)
PWK/PhJ	ENSLUMG00010026448	protein coding gene	Chr1:147214023-147366749 (+)
SPRET/EiJ	ENSMSPG00010005272	protein coding gene	Chr1:150575007-150722065 (+)
WSB/EiJ	ENSIUOG00005022133	protein coding gene	Chr1:147848840-147999543 (+)

Human Ortholog

NIBAN1, niban apoptosis regulator 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NIBAN1, niban apoptosis regulator 1
Synonyms

C1orf24, FAM129A, GIG39, NIBAN
Links

HGNC:16784

NCBI Gene ID: 116496

UniProt: Q9BZQ8
Chr Location

1q25.3; chr1:184790724-184974611 (-) GRCh38

MGI Vertebrate Homology

Niban1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NIBAN1
Gene Tree

Niban1

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

14
Targeted

3
Genomic Mutations

2 involving Niban1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

67 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable with no overt phenotypic abnormalities.

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All GO Annotations

13
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

663
Tissues

58
cDNA Data

18
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

74
RefSeq

6
UniProt

5
CCDS

CCDS48393.1

Ensembl

ENSMUSG00000026483 (Evidence)
NCBI Gene

63913

			Length	Strain/Species	Flank
genomic	63913	NCBI Gene Model \| MGI Sequence Detail	150476	C57BL/6J	± kb
transcript	NM_022018	RefSeq \| MGI Sequence Detail	6440	C57BL/6
polypeptide	Q3UW53	UniProt \| EBI \| MGI Sequence Detail	926	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000030908 protein Niban 1

(term hierarchy)
InterPro Domains

IPR059060 Niban 1/2/3 domain

IPR026088 Niban-like

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All nucleic 20

cDNA 18

Primer pair 1

Other 1

Microarray probesets 4

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MGI:2138185, MGI:2138451, MGI:6393849

Summaries

All 48

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 15
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Niban1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9392	Chr1:151446884-151446936 (+)	-305 bp
Tssr9393	Chr1:151447180-151447191 (+)	-29 bp
Tssr9394	Chr1:151447192-151447222 (+)	-8 bp
Tssr9395	Chr1:151447232-151447243 (+)	23 bp
Tssr9396	Chr1:151447992-151447996 (+)	779 bp
Tssr9397	Chr1:151479324-151479328 (+)	32,111 bp
Tssr9398	Chr1:151508101-151508104 (+)	60,888 bp
Tssr9399	Chr1:151552923-151552933 (+)	105,713 bp
Tssr9400	Chr1:151553751-151553759 (+)	106,540 bp
Tssr9401	Chr1:151594347-151594397 (+)	147,157 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24