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Hemgn Gene Detail
Summary
  • Symbol
    Hemgn
  • Name
    hemogen
  • Synonyms
    4921524M03Rik, EDAG
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136910
    NCBI Gene: 93966
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:46393989-46404183 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 24.73 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136910
 protein coding gene Chr4:46393989-46413506 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028257
 protein coding gene Chr4:44699782-44723332 (-)
A/J MGP_AJ_G0028216
 protein coding gene Chr4:43066838-43086434 (-)
AKR/J MGP_AKRJ_G0028166
 protein coding gene Chr4:44118133-44137880 (-)
BALB/cJ MGP_BALBcJ_G0028236
 protein coding gene Chr4:43170978-43190813 (-)
C3H/HeJ MGP_C3HHeJ_G0027957
 protein coding gene Chr4:44729690-44748924 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028677
 protein coding gene Chr4:46347151-46369813 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025986
 protein coding gene Chr4:40444920-40465150 (-)
CAST/EiJ MGP_CASTEiJ_G0027396
 protein coding gene Chr4:44271883-44296247 (-)
CBA/J MGP_CBAJ_G0027923
 protein coding gene Chr4:47822808-47852431 (-)
DBA/2J MGP_DBA2J_G0028073
 protein coding gene Chr4:42958790-42978476 (-)
FVB/NJ MGP_FVBNJ_G0028040
 protein coding gene Chr4:42207203-42226634 (-)
LP/J MGP_LPJ_G0028172
 protein coding gene Chr4:44753812-44775516 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028064
 protein coding gene Chr4:50909272-50928425 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028712
 protein coding gene Chr4:44336094-44357999 (-)
PWK/PhJ MGP_PWKPhJ_G0027121
 protein coding gene Chr4:43058709-43079555 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026949
 protein coding gene Chr4:43837341-43860111 (-)
WSB/EiJ MGP_WSBEiJ_G0027474
 protein coding gene Chr4:44248001-44268670 (-)



Homology
more
  • Human Ortholog
    HEMGN, hemogen
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HEMGN, hemogen
  • Synonyms
    CT155, EDAG, EDAG-1, NDR
  • Links
    NCBI Gene ID: 55363
    neXtProt AC: NX_Q9BXL5
    UniProt: Q9BXL5

  • Chr Location
    9q22.33; chr9:97926791-97944915 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced embryo and fetal size, reduced fetal liver weight, decreased erythroblast number, and impaired erythroid differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    822
  • Tissues
    61
  • cDNA Data
    37
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 93966 NCBI Gene Model | MGI Sequence Detail 10195 C57BL/6J ±  kb
    transcript NM_053149 RefSeq | MGI Sequence Detail 2310 C57BL/6  
    polypeptide Q9ERZ0 UniProt | EBI | MGI Sequence Detail 503 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 38

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1913968, MGI:2140231
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326018 Guo X, et al., Hemogen/BRG1 cooperativity modulates promoter and enhancer activation during erythropoiesis. Blood. 2022 Jun 16;139(24):3532-3545
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/21/2023
    MGI 6.22     		The Jackson Laboratory