Get1 MGI Mouse Gene Detail - MGI:2136882 - guided entry of tail-anchored proteins factor 1

Symbol

Get1
Name

guided entry of tail-anchored proteins factor 1
Synonyms

5530402J05Rik, C030018G21Rik, Chd5, Wrb

Feature Type

protein coding gene
IDs

MGI:2136882
NCBI Gene: 71446
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr16:95946607-95959052 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 56.84 cM
Mapping Data

2 experiments

SNPs within 2kb

83 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2136882	protein coding gene	Chr16:95946600-95959052 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023081	protein coding gene	Chr16:97511153-97523623 (+)
A/J	MGP_AJ_G0023049	protein coding gene	Chr16:92883891-92896331 (+)
AKR/J	MGP_AKRJ_G0023019	protein coding gene	Chr16:95754344-95766833 (+)
BALB/cJ	MGP_BALBcJ_G0023051	protein coding gene	Chr16:93441904-93454730 (+)
C3H/HeJ	MGP_C3HHeJ_G0022812	protein coding gene	Chr16:96278426-96290877 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023498	protein coding gene	Chr16:100607447-100619918 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021000	protein coding gene	Chr16:90737112-90751727 (+)
CAST/EiJ	MGP_CASTEiJ_G0022331	protein coding gene	Chr16:97071970-97084663 (+)
CBA/J	MGP_CBAJ_G0022781	protein coding gene	Chr16:104941611-104954058 (+)
DBA/2J	MGP_DBA2J_G0022915	protein coding gene	Chr16:92768432-92780902 (+)
FVB/NJ	MGP_FVBNJ_G0022889	protein coding gene	Chr16:91947295-91959752 (+)
LP/J	MGP_LPJ_G0022985	protein coding gene	Chr16:97142469-97154953 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022910	protein coding gene	Chr16:109168498-109180955 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023516	protein coding gene	Chr16:96284032-96296498 (+)
PWK/PhJ	MGP_PWKPhJ_G0022076	protein coding gene	Chr16:93068456-93081526 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021906	protein coding gene	Chr16:95825793-95838001 (+)
WSB/EiJ	MGP_WSBEiJ_G0022382	protein coding gene	Chr16:96549718-96562132 (+)

Human Ortholog

GET1, guided entry of tail-anchored proteins factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GET1, guided entry of tail-anchored proteins factor 1
Synonyms

CHD5, WRB
Links

HGNC:12790

NCBI Gene ID: 7485

neXtProt AC: NX_O00258

UniProt: O00258
Chr Location

21q22.2; chr21:39377698-39428528 (+) GRCh38

MGI Vertebrate Homology

Get1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GET1
Gene Tree

Get1

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References

6 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
92 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Gene trapped

21
Spontaneous

1
Targeted

9
Genomic Mutations

7 involving Get1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available

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All GO Annotations

22
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

990
Tissues

107
cDNA Data

53
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase get1

ZFIN get1

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All Sequences

48
RefSeq

2
UniProt

4
CCDS

CCDS28354.1

Ensembl

ENSMUSG00000023147 (Evidence)
NCBI Gene

71446

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023147	Ensembl Gene Model \| MGI Sequence Detail	12446	C57BL/6J	± kb
transcript	ENSMUST00000232832	Ensembl \| MGI Sequence Detail	2678	Not Applicable
polypeptide	ENSMUSP00000156449	Ensembl \| MGI Sequence Detail	224	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000017454 tryptophan-rich protein

(term hierarchy)
InterPro Domains

IPR028945 Get1 family

IPR029012 Helix hairpin bin domain superfamily

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All nucleic 56

cDNA 54

Primer pair 1

Other 1

Microarray probesets 3

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MGI:1918696, MGI:1924724

Summaries

All 125

Developmental Gene Expression 5

Diseases 6

Gene Ontology 6

Phenotypes 92
Earliest

J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
Latest

J:345472 Lana-Elola E, et al., Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome. Sci Transl Med. 2024 Jan 24;16(731):eadd6883

TSS for Get1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139631	Chr16:95946591-95946648 (+)	13 bp
Tssr139632	Chr16:95957873-95957883 (+)	11,271 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23