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BC004004 Gene Detail
Summary
  • Symbol
    BC004004
  • Name
    cDNA sequence BC004004
  • Synonyms
    2400006G15Rik, MGC:7550
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136782
    NCBI Gene: 80748
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:29487762-29521862 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 15.17 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    283 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136782
protein coding gene Chr17:29487762-29533039 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023461
protein coding gene Chr17:28783609-28823148 (+)
A/J MGP_AJ_G0023419
protein coding gene Chr17:27795977-27837361 (+)
AKR/J MGP_AKRJ_G0023384
protein coding gene Chr17:28028959-28065523 (+)
BALB/cJ MGP_BALBcJ_G0023424
protein coding gene Chr17:28063430-28098067 (+)
C3H/HeJ MGP_C3HHeJ_G0023185
protein coding gene Chr17:28414174-28456678 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023866
protein coding gene Chr17:29933040-29967837 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021341
protein coding gene Chr17:25125575-25161906 (+)
CAST/EiJ MGP_CASTEiJ_G0022686
protein coding gene Chr17:28394090-28432081 (+)
CBA/J MGP_CBAJ_G0023160
protein coding gene Chr17:31036460-31075454 (+)
DBA/2J MGP_DBA2J_G0023290
protein coding gene Chr17:27327015-27360703 (+)
FVB/NJ MGP_FVBNJ_G0023260
protein coding gene Chr17:27165435-27201613 (+)
LP/J MGP_LPJ_G0023368
protein coding gene Chr17:29035952-29075805 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023278
protein coding gene Chr17:30384853-30422895 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023908
protein coding gene Chr17:28495391-28533203 (+)
PWK/PhJ MGP_PWKPhJ_G0022436
protein coding gene Chr17:26167121-26204030 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022254
protein coding gene Chr17:26476568-26510399 (+)
WSB/EiJ MGP_WSBEiJ_G0022748
protein coding gene Chr17:28450030-28485288 (+)



Homology
more
  • Human Ortholog
    C6orf89, chromosome 6 open reading frame 89
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C6orf89, chromosome 6 open reading frame 89
  • Synonyms
    BRAP, PS1TP5TP1
  • Links
    NCBI Gene ID: 221477
    neXtProt AC: NX_Q6UWU4
    UniProt: Q6UWU4

  • Chr Location
    6p21.2; chr6:36871844-36928964 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation has no notable phenotype in any parameter tested. Another knock-out allele shows attenuation of pulmonary injury and fibrosis and enhanced autophagy in the lungs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 80748 NCBI Gene Model | MGI Sequence Detail 34101 C57BL/6J ±  kb
transcript NM_030561 RefSeq | MGI Sequence Detail 2809 C57BL/6  
polypeptide Q99KU6 UniProt | EBI | MGI Sequence Detail 348 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 97
    cDNA 97

    Microarray probesets 6
Other
Accession IDs
less
MGI:1916975
References
more
  • Summaries
    All 33
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:332577 Yao X, et al., Lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice. Stress. 2023 Jan;26(1):1-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
02/13/2024
MGI 6.23
The Jackson Laboratory