Pcdhb17 MGI Mouse Gene Detail - MGI:2136754

Symbol

Pcdhb17
Name

protocadherin beta 17
Synonyms

mKIAA1621, Pcdhb16, PcdhbQ

Feature Type

protein coding gene
IDs

MGI:2136754
NCBI Gene: 93888
Member of

Pcdhb cluster
Alliance

genome feature page
Transcription Start Sites

1 TSS
Regulated by

Rr72, Rr73, Rr74 (3 regulatory regions)

Sequence Map

Chr18:37618040-37621345 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 19.50 cM, cytoband B3
Mapping Data

1 experiment

SNPs within 2kb

143 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2136754	protein coding gene	Chr18:37617848-37622507 (+)
129S1/SvImJ	ENSMUSG00200042541	protein coding gene	Chr18:34607052-34611712 (+)
A/J	ENSMUSG00195034802	protein coding gene	Chr18:34768569-34773229 (+)
AKR/J	ENSMUSG00220016181	protein coding gene	Chr18:34750165-34754825 (+)
BALB/cJ	ENSMUSG00180015431	protein coding gene	Chr18:35218191-35222851 (+)
C3H/HeJ	ENSMUSG00175034682	protein coding gene	Chr18:34740315-34744978 (+)
C57BL/6NJ	ENSMUSG00215019432	protein coding gene	Chr18:34487374-34492034 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022173	protein coding gene	Chr18:34706119-34710785 (+)
CAST/EiJ	ENSTCUG00005021463	protein coding gene	Chr18:34359241-34363899 (+)
CBA/J	ENSMUSG00210021074	protein coding gene	Chr18:34760211-34764871 (+)
DBA/2J	ENSMUSG00185017451	protein coding gene	Chr18:34694848-34699508 (+)
FVB/NJ	ENSMUSG00205024320	protein coding gene	Chr18:34411962-34416622 (+)
JF1/MsJ	ENSUMUG00000044956	protein coding gene	Chr18:34831367-34836017 (+)
LP/J	ENSMUSG00230043177	protein coding gene	Chr18:36803720-36808380 (+)
NOD/ShiLtJ	ENSMUSG00190017305	protein coding gene	Chr18:34488615-34493278 (+)
NZO/HlLtJ	ENSMUSG00225045604	protein coding gene	Chr18:36710394-36715055 (+)
PWK/PhJ	ENSLUMG00010011650	protein coding gene	Chr18:34997471-35002131 (+)
SPRET/EiJ	ENSMSPG00010021780	protein coding gene	Chr18:35034363-35037912 (+)
WSB/EiJ	ENSIUOG00005006837	protein coding gene	Chr18:34465386-34470047 (+)

Human Ortholog

PCDHB16, protocadherin beta 16

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PCDHB16, protocadherin beta 16
Synonyms

ME1, PCDH3X, PCDHB8a, PCDH-BETA16
Links

HGNC:14546

NCBI Gene ID: 57717

UniProt: Q9NRJ7
Chr Location

5q31.3; chr5:141182387-141186226 (+) GRCh38

MGI Vertebrate Homology

Pcdhb17 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PCDHB16
Gene Tree

Pcdhb17

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Phenotype Summary

7 phenotype references

All Mutations and Alleles

10
Endonuclease-mediated

1
Targeted

9
Genomic Mutations

8 involving Pcdhb17
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

56 strains or lines available

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

607
Tissues

4
cDNA Data

3
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

2
UniProt

4
CCDS

CCDS29183.1

Ensembl

ENSMUSG00000046387 (Evidence)
NCBI Gene

93888

			Length	Strain/Species	Flank
genomic	93888	NCBI Gene Model \| MGI Sequence Detail	3306	C57BL/6J	± kb
transcript	NM_053142	RefSeq \| MGI Sequence Detail	3306	C57BL/6
polypeptide	NP_444372	RefSeq \| MGI Sequence Detail	799	C57BL/6

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UniProt

4 Sequences
InterPro Domains

IPR020894 Cadherin conserved site

IPR032455 Cadherin, cytoplasmic C-terminal domain

IPR002126 Cadherin-like

IPR015919 Cadherin-like superfamily

IPR013164 Cadherin, N-terminal

IPR050174 Protocadherin/Cadherin-related Cell Adhesion

IPR010221 VCBS domain
GlyGen

Q91VD8 1 site, 1 N-linked glycan (1 site)

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All nucleic 6

cDNA 3

Primer pair 3

Microarray probesets 4

Summaries

All 36

Developmental Gene Expression 8

Gene Ontology 4

Phenotypes 7
Earliest

J:86878 Wu Q, et al., A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90
Latest

J:332241 Kobayashi H, et al., Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality. iScience. 2023 Jan 20;26(1):105766

Pcdhb17 expression regulated by:

Feature	Feature Type	Location	Reference
Rr72, regulatory region 72	unclassified other genome feature	Chr18, Syntenic	J:277249
Rr73, regulatory region 73	unclassified other genome feature	Chr18, Syntenic	J:277249
Rr74, regulatory region 74	unclassified other genome feature	Chr18, Syntenic	J:277249

TSS for Pcdhb17:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150709	Chr18:37618008-37618081 (+)	5 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24