Pcdhb7 Gene Detail

Summary

• Symbol
  Pcdhb7
• Name
  protocadherin beta 7
• Synonyms
  Pcdhb4B, PcdhbG

• Feature Type
  protein coding gene
• IDs
  MGI:2136741
  NCBI Gene: 93878
• Member of
  Pcdhb cluster
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr18:37474755-37478255 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 18, 19.47 cM, cytoband B3
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  106 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2136741	protein coding gene	Chr18:37474755-37478260 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024316	protein coding gene	Chr18:35737528-35741468 (+)
A/J	MGP_AJ_G0024283	protein coding gene	Chr18:34528506-34532005 (+)
AKR/J	MGP_AKRJ_G0024251	protein coding gene	Chr18:35481585-35486009 (+)
BALB/cJ	MGP_BALBcJ_G0024282	protein coding gene	Chr18:34557556-34562363 (+)
C3H/HeJ	MGP_C3HHeJ_G0024049	protein coding gene	Chr18:35542415-35545914 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024724	protein coding gene	Chr18:37036299-37039920 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022163	protein coding gene	Chr18:34587811-34591285 (+)
CAST/EiJ	MGP_CASTEiJ_G0023524	protein coding gene	Chr18:35508790-35514618 (+)
CBA/J	MGP_CBAJ_G0024018	protein coding gene	Chr18:38120280-38125468 (+)
DBA/2J	MGP_DBA2J_G0024148	protein coding gene	Chr18:34118971-34122470 (+)
FVB/NJ	MGP_FVBNJ_G0024115	protein coding gene	Chr18:33839545-33843039 (+)
LP/J	MGP_LPJ_G0024232	protein coding gene	Chr18:35830167-35834755 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024145	protein coding gene	Chr18:39389620-39393746 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024773	protein coding gene	Chr18:35336508-35340007 (+)
PWK/PhJ	MGP_PWKPhJ_G0023269	protein coding gene	Chr18:34357173-34360877 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023074	protein coding gene	Chr18:35587051-35590550 (+)
WSB/EiJ	MGP_WSBEiJ_G0023587	protein coding gene	Chr18:35238691-35243538 (+)

Homology

• Human Ortholog
  PCDHB4, protocadherin beta 4

• Vertebrate Orthologs
  13

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  PCDHB4, protocadherin beta 4
  
• Synonyms
  PCDH-BETA4
• Links
  HGNC:8689

  NCBI Gene ID: 56131

  neXtProt AC: NX_Q9Y5E5

  UniProt: Q9Y5E5

  
  
• Chr Location
  5q31.3; chr5:141121750-141125623 (+)  GRCh38.p7

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• Alliance of Genome Resources
  Pcdhb7 stringent orthology
  1 human;1 mouse;1 rat;11 zebrafish
  
• HCOP
  vertebrate homology predictions: PCDHB4
• Gene Tree
  Pcdhb7
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotype references
  

• All Mutations and Alleles
  4
• Targeted
  4
• Genomic Mutations
  4 involving Pcdhb7
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  27 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  732
• Tissues
  24
• cDNA Data
  6
• Literature Summary
  3

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Interactions

• Pcdhb7 interacts with 179 markers (Mir15a, Mir15b, Mir16-1, ...) View All

Sequences &
Gene Models

• All Sequences
  41
• RefSeq
  2
• UniProt
  6
• CCDS
  CCDS50257.1

• Ensembl
  ENSMUSG00000045062 (Evidence)
• NCBI Gene
  93878

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000045062	Ensembl Gene Model | MGI Sequence Detail	3501	C57BL/6J
transcript	ENSMUST00000053037	Ensembl | MGI Sequence Detail	3501	Not Applicable
polypeptide	ENSMUSP00000051041	Ensembl | MGI Sequence Detail	829	Not Applicable

Protein
Information

• UniProt
  6 Sequences
• InterPro Domains
  IPR020894 Cadherin conserved site
  IPR032455 Cadherin, cytoplasmic C-terminal domain
  IPR002126 Cadherin-like
  IPR015919 Cadherin-like superfamily
  IPR013164 Cadherin, N-terminal

Molecular
Reagents

• All nucleic 7

  cDNA 6

  Primer pair 1

  
  

  Microarray probesets 3

References

• Summaries
  All 24

  Developmental Gene Expression 3

  Gene Ontology 1

  Phenotypes 4
• Earliest
  J:67989 Wu Q, et al., Comparative dna sequence analysis of mouse and human protocadherin gene clusters. Genome Res. 2001 Mar;11(3):389-404
• Latest
  J:332241 Kobayashi H, et al., Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality. iScience. 2023 Jan 20;26(1):105766

TSS for Pcdhb7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150698	Chr18:37474768-37474781 (+)	20 bp
Tssr150699	Chr18:37474797-37474809 (+)	48 bp