Wnt16 MGI Mouse Gene Detail - MGI:2136018 - wingless-type MMTV integration site family, member 16

Symbol

Wnt16
Name

wingless-type MMTV integration site family, member 16
Synonyms

E130309I19Rik

Feature Type

protein coding gene
IDs

MGI:2136018
NCBI Gene: 93735
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr6:22288226-22298521 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 9.22 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

138 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2136018	protein coding gene	Chr6:22288179-22298521 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030483	protein coding gene	Chr6:19789698-19800326 (+)
A/J	MGP_AJ_G0030456	protein coding gene	Chr6:18971840-18982125 (+)
AKR/J	MGP_AKRJ_G0030383	protein coding gene	Chr6:19575945-19586225 (+)
BALB/cJ	MGP_BALBcJ_G0030465	protein coding gene	Chr6:19050633-19061497 (+)
C3H/HeJ	MGP_C3HHeJ_G0030179	protein coding gene	Chr6:19523107-19533404 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030920	protein coding gene	Chr6:20385802-20396098 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028131	protein coding gene	Chr6:17573734-17583980 (+)
CAST/EiJ	MGP_CASTEiJ_G0029581	protein coding gene	Chr6:19466817-19477210 (+)
CBA/J	MGP_CBAJ_G0030157	protein coding gene	Chr6:21067763-21078058 (+)
DBA/2J	MGP_DBA2J_G0030301	protein coding gene	Chr6:18876020-18886312 (+)
FVB/NJ	MGP_FVBNJ_G0030255	protein coding gene	Chr6:18671788-18682070 (+)
LP/J	MGP_LPJ_G0030388	protein coding gene	Chr6:19901850-19912191 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030291	protein coding gene	Chr6:22895400-22905503 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030950	protein coding gene	Chr6:19532984-19543271 (+)
PWK/PhJ	MGP_PWKPhJ_G0029295	protein coding gene	Chr6:18554698-18565071 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029131	protein coding gene	Chr6:19273541-19283783 (+)
WSB/EiJ	MGP_WSBEiJ_G0029657	protein coding gene	Chr6:19422987-19433538 (+)

Human Ortholog

WNT16, Wnt family member 16

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WNT16, Wnt family member 16
Links

HGNC:16267

NCBI Gene ID: 51384

neXtProt AC: NX_Q9UBV4

UniProt: Q9UBV4
Chr Location

7q31.31; chr7:121325367-121341104 (+) GRCh38

MGI Vertebrate Homology

Wnt16 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WNT16
Gene Tree

Wnt16

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

3
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased bone mineral density, cortical bone thickness and bone strength.

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All GO Annotations

28
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1146
Tissues

390
cDNA Data

12
Literature Summary

53

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA WNT16

Xenbase wnt16

ZFIN wnt16

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All Sequences

43
RefSeq

4
UniProt

5
CCDS

CCDS19936.1

Ensembl

ENSMUSG00000029671 (Evidence)
NCBI Gene

93735

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029671	Ensembl Gene Model \| MGI Sequence Detail	10296	C57BL/6J	± kb
transcript	ENSMUST00000031681	Ensembl \| MGI Sequence Detail	1663	Not Applicable
polypeptide	ENSMUSP00000031681	Ensembl \| MGI Sequence Detail	364	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000017439 protein Wnt-16

(term hierarchy)
InterPro Domains

IPR005817 Wnt

IPR013304 Wnt-16 protein

IPR043158 Wnt, C-terminal domain

IPR018161 Wnt protein, conserved site

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All nucleic 25

Genomic 1

cDNA 13

Primer pair 8

Other 3

Microarray probesets 2

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MGI:2444753

Summaries

All 96

Developmental Gene Expression 53

Gene Ontology 5

Phenotypes 17
Earliest

J:57926 McWhirter JR, et al., Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11464-9
Latest

J:344215 Behrmann A, et al., Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz (Wwtr1) Activation in Male LDLR-/- Mice. Endocrinology. 2023 Dec 23;165(2)

TSS for Wnt16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr55151	Chr6:22288220-22288237 (+)	3 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23